{"id":"W4408875172","doi":"10.1101/2025.03.25.25324477","title":"Evaluation of a DNA methylation-based measure of chronic inflammation in two generations of adults in metropolitan Cebu, Philippines","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Metropolitan area; Measure (data warehouse); DNA methylation; Inflammation; Gerontology; Biology; Genetics; Medicine; Geography; Gene; Internal medicine; Computer science; Pathology; Data mining","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007540617,0.0004949367,0.0001905206,0.000679137,0.0007064053,0.0004422596,0.0005371305,0.0004400134,0.000780092],"category_scores_gemma":[0.001779016,0.0001986305,0.000213333,0.0005248094,0.0002924987,0.0002206878,0.0007144344,0.0003332839,0.0001571113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000669532,"about_ca_system_score_gemma":0.0004062976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.03874873,"about_ca_topic_score_gemma":0.0412799,"domain_scores_codex":[0.9996192,0.0001661896,0.00001942776,0.00008641499,0.00005188434,0.00005691444],"domain_scores_gemma":[0.999357,0.00007415974,0.0001785477,0.00005575669,0.0001951404,0.0001392974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006523317,0.00002997847,0.9960448,0.000009004053,0.00002474709,0.00009175178,0.0009448243,0.00004302145,0.0009188568,0.000009460226,0.0000543348,0.001764104],"study_design_scores_gemma":[0.000004128879,0.0001708787,0.997954,0.000004573017,0.00001411593,0.0001439042,0.0009466882,0.0003168878,0.0002689341,0.00001104073,0.0001610947,0.000003752732],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995286,0.00004374694,0.0001151765,0.00002487245,0.000001459578,0.00001381933,0.0001464391,0.000003135535,0.000122709],"genre_scores_gemma":[0.9995047,0.00001983555,0.0001729973,0.00001819001,0.000002102287,0.00002349875,0.00009510427,0.00000117847,0.000162395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03874873,"threshold_uncertainty_score":0.07704639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03021330707669704,"score_gpt":0.325746313281267,"score_spread":0.29553300620457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}