{"id":"W4408875876","doi":"10.1101/2025.03.21.644417","title":"Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategies","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Diet and metabolism studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Dopamine transporter; Dopamine; Transporter; Neuroscience; Medicine; Pharmacology; Biology; Dopaminergic; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005320606,0.001858341,0.0007152335,0.002097689,0.000618729,0.0008069886,0.0009383011,0.001906691,0.00405167],"category_scores_gemma":[0.0002718849,0.0005377359,0.00100009,0.0004997008,0.0008579514,0.0007137154,0.0004640166,0.0024956,0.001605904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007580493,"about_ca_system_score_gemma":0.0005208511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001050097,"about_ca_topic_score_gemma":0.001553686,"domain_scores_codex":[0.9993704,0.00007460244,0.0001134706,0.0001788345,0.0001566932,0.000106087],"domain_scores_gemma":[0.9994839,0.00007274041,0.0001430126,0.00004835391,0.00007002118,0.0001818929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002956612,0.0004736648,0.0003682762,0.00006494139,0.00003401019,0.0005403574,0.00004477357,0.0001783091,0.9939213,0.001081685,0.0003553311,0.002641788],"study_design_scores_gemma":[0.0006788727,0.003932185,0.006154405,0.0001189381,0.0002147949,0.005328066,0.0001838211,0.004538525,0.9541662,0.0008099015,0.0238118,0.00006243381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9348747,0.002784337,0.03938756,0.002131995,0.000510495,0.001428093,0.01084531,0.001487194,0.006550348],"genre_scores_gemma":[0.9135314,0.003526982,0.03939226,0.0008827689,0.000136967,0.002646693,0.01207312,0.0005277565,0.02728195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00405167,"threshold_uncertainty_score":0.01355416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03078445664632272,"score_gpt":0.2595283745926337,"score_spread":0.228743917946311,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}