{"id":"W4408889512","doi":"10.1126/sciadv.ads3227","title":"HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Broad Institute; Novo Nordisk; Universidad de Sevilla","keywords":"Homologous recombination; Base excision repair; DNA replication; AP site; DNA repair; RAD51; DNA; Biology; Genome instability; Molecular biology; Replication protein A; Cell biology; DNA damage; Chemistry; Genetics; DNA-binding protein; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001480427,0.0002196388,0.0002758363,0.0001795032,0.0001086526,0.0002256262,0.0001927857,0.0002773505,0.001605987],"category_scores_gemma":[0.0001582184,0.0001301066,0.0001309364,0.0001431766,0.0001618833,0.0001624827,0.0002198133,0.0004285449,0.0003322857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373077,"about_ca_system_score_gemma":0.0001341064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005354066,"about_ca_topic_score_gemma":0.0005651003,"domain_scores_codex":[0.9998185,0.0000360531,0.00002382871,0.00003880025,0.00005242564,0.00003041211],"domain_scores_gemma":[0.999745,0.00005913561,0.0000622701,0.00005227526,0.00002502093,0.00005637692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004532797,0.00001029777,0.0002016624,0.00001506659,0.000003191227,0.00003072486,0.000007074203,0.00002922558,0.9990532,0.00003827313,0.00001496083,0.0005509511],"study_design_scores_gemma":[0.000003549889,0.0001213577,0.003400011,0.00000166807,0.000004695866,0.0001182458,0.000009970135,0.0002662259,0.9954456,0.00001472202,0.0006126594,0.000001208946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962507,0.001293109,0.001181258,0.00005268283,0.00001658888,0.00001085229,0.0003049713,0.00005604492,0.0008338342],"genre_scores_gemma":[0.9962087,0.0004539951,0.0008461059,0.00004366439,0.000006854474,0.00001546301,0.0004626641,0.00001557787,0.001946912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001605987,"threshold_uncertainty_score":0.005372584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009318338112440788,"score_gpt":0.2832609725235208,"score_spread":0.27394263441108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}