{"id":"W4408899521","doi":"10.1016/j.molcel.2025.03.004","title":"Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms","year":2025,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research","funders":"National Institute of General Medical Sciences; Belgian American Educational Foundation; Melanoma Research Foundation; National Human Genome Research Institute; Wallonie-Bruxelles International; Charles A. King Trust; Fonds De La Recherche Scientifique - FNRS; Melanoma Research Alliance; National Cancer Institute; National Institutes of Health; Andrew Sabin Family Foundation; Fonds Léon Fredericq","keywords":"Biology; Transcription factor; Gene isoform; Variation (astronomy); Computational biology; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004588064,0.0001702465,0.0004634926,0.001130542,0.0002766425,0.0005058075,0.0004690679,0.0004221132,0.001791828],"category_scores_gemma":[0.001100783,0.0003239136,0.0003204348,0.0006393931,0.0004630902,0.0003557944,0.0004683218,0.000605494,0.0004584213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001812119,"about_ca_system_score_gemma":0.00009065601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006254615,"about_ca_topic_score_gemma":0.0009410528,"domain_scores_codex":[0.9993514,0.0000964819,0.00005778542,0.0003023567,0.0001121868,0.00007968541],"domain_scores_gemma":[0.9982134,0.000775683,0.0003050067,0.0003680697,0.0001326717,0.0002051432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002101853,0.00001829785,0.009198619,0.00001952773,0.00005555622,0.00006131762,0.00008296623,0.0000717969,0.9873838,0.0002603434,0.00003201416,0.002605662],"study_design_scores_gemma":[0.0000354101,0.0001674036,0.8507049,0.00001133212,0.00009779214,0.002196914,0.0001865468,0.001467062,0.1423279,0.001235791,0.001533295,0.00003572368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960906,0.0004311213,0.002288007,0.0000271459,0.000008157154,0.000006242068,0.0003610681,0.0000448197,0.0007428488],"genre_scores_gemma":[0.9979462,0.0001131321,0.0007556161,0.00003544677,0.00001140298,0.00001014653,0.0004399132,0.00003741177,0.0006506882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791828,"threshold_uncertainty_score":0.00599426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004137365612858731,"score_gpt":0.1909724569667155,"score_spread":0.1868350913538568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}