{"id":"W4408899550","doi":"10.20944/preprints202503.2053.v1","title":"Canadian Recommendations for Germline Genetic Testing of Patients with Breast Cancer: A Call to Action","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Germline; Action (physics); Genetic testing; Call to action; Cancer; Breast cancer; Medicine; Oncology; Internal medicine; Biology; Genetics; Business; Advertising; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05120714,0.001212589,0.001733068,0.004932751,0.008684587,0.008277546,0.008640338,0.01997992,0.01106745],"category_scores_gemma":[0.133477,0.001271826,0.004141256,0.005886304,0.008239398,0.005142582,0.005822766,0.02486396,0.004129567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.07369146,"about_ca_system_score_gemma":0.4026367,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9411756,"about_ca_topic_score_gemma":0.9585013,"domain_scores_codex":[0.9550963,0.01046484,0.00457201,0.00203327,0.02292686,0.004906793],"domain_scores_gemma":[0.7312094,0.04062436,0.00428272,0.006525528,0.1838815,0.03347653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000267831,0.00004470899,0.001412087,0.000290262,0.00003071453,0.0002088212,0.0006768542,0.0001820462,0.0002259284,0.004909622,0.966257,0.02573527],"study_design_scores_gemma":[0.00009869813,0.00002219953,0.004473191,0.001973285,0.00008041714,0.0002363136,0.001622569,0.0003320421,0.000231131,0.005580067,0.9851778,0.0001722671],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.0005825852,0.006216657,0.002042955,0.9692135,0.007748263,0.0002659658,0.001139615,0.0002941369,0.01249623],"genre_scores_gemma":[0.0205586,0.02296107,0.0720507,0.8413602,0.004744063,0.00069709,0.004570651,0.0004885225,0.03256916],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.07369146,"threshold_uncertainty_score":0.5346715,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07396221613808399,"score_gpt":0.3594415490845058,"score_spread":0.2854793329464218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}