{"id":"W4408907087","doi":"10.1016/j.antiviral.2025.106151","title":"Tenofovir alafenamide promotes weight gain and impairs fatty acid metabolism-related signaling pathways in visceral fat tissue compared to tenofovir disoproxil fumarate","year":2025,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health","keywords":"Tenofovir alafenamide; Tenofovir; Pharmacology; Metabolism; Fatty acid metabolism; Medicine; Chemistry; Endocrinology; Human immunodeficiency virus (HIV); Virology; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002268736,0.0004637954,0.001111913,0.001338749,0.000371968,0.000146209,0.0003810252,0.0003002698,0.00007031201],"category_scores_gemma":[0.0007600721,0.0003787889,0.0001263014,0.002303138,0.0004219775,0.0003561934,0.000544338,0.001284296,0.0002514264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001406904,"about_ca_system_score_gemma":0.0004087067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009047319,"about_ca_topic_score_gemma":0.0002008813,"domain_scores_codex":[0.995073,0.0006816164,0.0007923511,0.001018838,0.0009399751,0.001494179],"domain_scores_gemma":[0.9982266,0.0003170728,0.00008439078,0.0006543024,0.0003700828,0.0003475697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007531639,0.0004073145,0.01461267,0.0002393639,0.000181259,0.0005019291,0.002149362,0.000004906849,0.938078,0.003876524,0.001482542,0.03771298],"study_design_scores_gemma":[0.005363183,0.0006232343,0.1507818,0.001021463,0.0001800489,0.00003374066,0.001066979,0.001502316,0.8235639,0.005014356,0.01019151,0.0006575133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9801309,0.006156006,0.0003163387,0.004533349,0.0001962452,0.002359507,0.00003905796,0.0001413818,0.006127177],"genre_scores_gemma":[0.9908981,0.0004683171,0.001159252,0.0003260704,0.0001920838,0.0001576796,0.000075185,0.00006907543,0.006654266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1361691,"threshold_uncertainty_score":0.9998664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04103409760759242,"score_gpt":0.3564029374775032,"score_spread":0.3153688398699108,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}