{"id":"W4408921547","doi":"10.1097/ypg.0000000000000392","title":"A review of antipsychotic therapy effectiveness and tolerability among individuals with copy number variants relevant to schizophrenia","year":2025,"lang":"en","type":"review","venue":"Psychiatric Genetics","topic":"Genomic variations and chromosomal abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotchkiss Brain Institute; University of Calgary","funders":"","keywords":"Copy-number variation; Schizophrenia (object-oriented programming); Antipsychotic; Tolerability; Context (archaeology); Medicine; Psychiatry; Psychosis; Genome-wide association study; Bioinformatics; Genetics; Genome; Biology; Adverse effect; Internal medicine; Genotype; Single-nucleotide polymorphism; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001109978,0.0007351888,0.001976927,0.003911066,0.0002033593,0.0008199997,0.000833847,0.0006760655,0.002876912],"category_scores_gemma":[0.002842722,0.0003228865,0.001374656,0.004085828,0.0002770173,0.0008209973,0.0004819914,0.0006041975,0.0004439274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007874235,"about_ca_system_score_gemma":0.001520623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00196688,"about_ca_topic_score_gemma":0.003514762,"domain_scores_codex":[0.999447,0.0001171373,0.0002242547,0.00007675663,0.0001117978,0.00002303004],"domain_scores_gemma":[0.9982405,0.001263562,0.0002495835,0.00002305103,0.000189211,0.00003413317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0002192913,0.00004339498,0.0005617326,0.2343443,0.001103332,0.000284318,0.0001642098,0.0002412615,0.0008952544,0.0006852705,0.01776838,0.7436893],"study_design_scores_gemma":[0.000121602,0.0006131943,0.01104749,0.2214014,0.009586764,0.006263063,0.0003305923,0.0001775306,0.001019355,0.001162266,0.748189,0.00008766956],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001888952,0.9993375,0.00002875219,0.00009192499,0.00006119696,0.000005139251,0.00004680388,0.000002929067,0.0002368498],"genre_scores_gemma":[0.000889194,0.9987611,0.00008689003,0.00009802092,0.00004750472,0.000006007082,0.0000413599,0.000001218376,0.00006869923],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003911066,"threshold_uncertainty_score":0.009624243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079625255205376,"score_gpt":0.2919726246965236,"score_spread":0.2811763721444699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}