{"id":"W4408922776","doi":"10.1136/jitc-2024-011273","title":"Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events","year":2025,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; National Heart, Lung, and Blood Institute; U.S. Food and Drug Administration; Fiona and Stanley Druckenmiller Center for Lung Cancer Research; National Cancer Institute; National Institutes of Health; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Princess Margaret Cancer Foundation; Larry L. Hillblom Foundation","keywords":"Discontinuation; Adverse effect; Immune system; Medicine; Immune checkpoint; Immunology; Immunotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214512,0.0002463334,0.0002795561,0.0004554027,0.0001742706,0.0004564869,0.000328935,0.0003121706,0.002321733],"category_scores_gemma":[0.004128095,0.0001448971,0.001087351,0.0004340577,0.0001990185,0.0002307656,0.0003565536,0.0005293468,0.0001594007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245808,"about_ca_system_score_gemma":0.0002647422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003065204,"about_ca_topic_score_gemma":0.003100522,"domain_scores_codex":[0.9993399,0.0001875632,0.00005132889,0.0002330485,0.0000861483,0.000101961],"domain_scores_gemma":[0.9959313,0.001423004,0.001875126,0.000290927,0.0001528953,0.0003266766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001550382,0.00001085609,0.996454,0.00000680674,0.0001312594,0.00003627321,0.000006921636,0.0005309562,0.0002196626,0.00003099773,0.00009024679,0.002326992],"study_design_scores_gemma":[0.00001538899,0.0001505356,0.9959213,0.000006025219,0.0001115939,0.000292422,0.00001606325,0.003025596,0.0001586283,0.0001120148,0.0001863824,0.000004076692],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974915,0.0005197101,0.0008204423,0.0001023509,0.00001455801,0.000007907985,0.0005642742,0.00002346594,0.0004559102],"genre_scores_gemma":[0.9994579,0.00005100161,0.0001306775,0.00001841375,0.000009122215,0.000001897699,0.000240635,0.000002161313,0.00008815835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003065204,"threshold_uncertainty_score":0.007766902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334862461884169,"score_gpt":0.3210786169146588,"score_spread":0.3077299922958171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}