{"id":"W4408936178","doi":"10.1016/s2214-109x(24)00511-4","title":"Strengthening the paediatric clinical trial ecosystem to better inform policy and programmes","year":2025,"lang":"en","type":"review","venue":"The Lancet Global Health","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"European and Developing Countries Clinical Trials Partnership; Egerton University; Government of the United Kingdom; Department of Health and Social Care; World Health Organization; National Institute for Health and Care Research; Bill and Melinda Gates Foundation","keywords":"Ecosystem; MEDLINE; Environmental planning; Environmental resource management; Medicine; Economic growth; Political science; Geography; Environmental science; Ecology; Economics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003781538,0.0003117044,0.002291709,0.00004191908,0.0003396486,0.00008565923,0.000374624,0.0001648731,0.000007523753],"category_scores_gemma":[0.001625111,0.0001309227,0.0003362697,0.0007722528,0.00006920923,0.00003326069,0.0004060395,0.0008840996,0.00004242612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003190465,"about_ca_system_score_gemma":0.001550867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002538913,"about_ca_topic_score_gemma":0.0001580933,"domain_scores_codex":[0.9967733,0.0007549389,0.001141505,0.0003179715,0.0003234543,0.0006888262],"domain_scores_gemma":[0.9959617,0.002644437,0.000533962,0.0004950857,0.00004395562,0.0003209196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001246476,0.00003923751,0.000063711,0.009052332,0.0002522984,0.000002410673,0.00004495361,2.538824e-8,4.185102e-11,0.001123892,0.01915826,0.9690164],"study_design_scores_gemma":[0.004415286,0.0006205878,0.0001034505,0.00367302,0.0008012953,0.0000362214,0.00004228004,0.000003065444,1.025598e-9,0.00008910956,0.9901075,0.000108218],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000626569,0.913233,0.000004873829,0.07751767,0.0007004995,0.00383864,0.0002143291,0.00005800928,0.004370264],"genre_scores_gemma":[0.00007623897,0.9635714,0.0001185731,0.02623536,0.009710887,0.0001846172,0.00002095711,0.00001081001,0.00007117026],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9709492,"threshold_uncertainty_score":0.5338873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2446303590179075,"score_gpt":0.575903442308487,"score_spread":0.3312730832905795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}