{"id":"W4408936365","doi":"10.1016/s2214-109x(24)00553-9","title":"Predicted dolutegravir resistance in people living with HIV in South Africa during 2020–35: a modelling study","year":2025,"lang":"en","type":"article","venue":"The Lancet Global Health","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Università degli Studi di Roma Tor Vergata; Deutschen Konsortium für Translationale Krebsforschung; Bundesministerium für Bildung und Forschung; Universität Zürich; Astellas Pharma; NordForsk; Bundesministerium für Gesundheit; ViiV Healthcare; Ministerie van Volksgezondheid, Welzijn en Sport; HORIZON EUROPE Framework Programme; Gilead Sciences; University of Bristol; Istituto Superiore di Sanità; Styrelsen för Internationellt Utvecklingssamarbete; National Institute on Alcohol Abuse and Alcoholism; British HIV Association; Rigshospitalet; Bill and Melinda Gates Foundation; Deutsches Zentrum für Infektionsforschung; National Institutes of Health; Shionogi; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Ministero della Salute; Pfizer; National Science Foundation","keywords":"Dolutegravir; Human immunodeficiency virus (HIV); Virology; Medicine; Resistance (ecology); Environmental health; Antiretroviral therapy; Biology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001443075,0.000696928,0.0005255037,0.0008416674,0.0004696265,0.001128899,0.001223331,0.001397046,0.003078267],"category_scores_gemma":[0.004719498,0.0005252924,0.001868125,0.0009082573,0.0004000316,0.0009668012,0.001017343,0.001027512,0.0003618846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002438674,"about_ca_system_score_gemma":0.001548241,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.08794121,"about_ca_topic_score_gemma":0.03753586,"domain_scores_codex":[0.9996475,0.0001382736,0.00002036308,0.00007602349,0.00002230778,0.0000955242],"domain_scores_gemma":[0.9980564,0.001162362,0.0003507326,0.0001021835,0.0001634573,0.0001648655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0007093823,0.0002896897,0.3281855,0.0001690042,0.000545373,0.001048751,0.0008181699,0.653061,0.0007259139,0.003427675,0.001914939,0.009104588],"study_design_scores_gemma":[0.0001287706,0.0002524862,0.06338883,0.0001018421,0.0001809107,0.0004455111,0.0009640221,0.9299708,0.0002531005,0.002541317,0.001721775,0.00005057098],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935625,0.0001687336,0.002388657,0.0006153465,0.000009951491,0.00004839078,0.002014994,0.00002637269,0.001165099],"genre_scores_gemma":[0.9970526,0.0001442965,0.001225316,0.00005346245,0.000006318811,0.00005480225,0.0009417441,0.000007110566,0.0005144561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08794121,"threshold_uncertainty_score":0.1748586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738466737035009,"score_gpt":0.2896564506497855,"score_spread":0.2722717832794354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}