{"id":"W4408936365","doi":"10.1016/s2214-109x(24)00553-9","title":"Predicted dolutegravir resistance in people living with HIV in South Africa during 2020–35: a modelling study","year":2025,"lang":"en","type":"article","venue":"The Lancet Global Health","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; Università degli Studi di Roma Tor Vergata; Deutschen Konsortium für Translationale Krebsforschung; Bundesministerium für Bildung und Forschung; Universität Zürich; Astellas Pharma; NordForsk; Bundesministerium für Gesundheit; ViiV Healthcare; Ministerie van Volksgezondheid, Welzijn en Sport; HORIZON EUROPE Framework Programme; Gilead Sciences; University of Bristol; Istituto Superiore di Sanità; Styrelsen för Internationellt Utvecklingssamarbete; National Institute on Alcohol Abuse and Alcoholism; British HIV Association; Rigshospitalet; Bill and Melinda Gates Foundation; Deutsches Zentrum für Infektionsforschung; National Institutes of Health; Shionogi; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Ministero della Salute; Pfizer; National Science Foundation","keywords":"Dolutegravir; Human immunodeficiency virus (HIV); Virology; Medicine; Resistance (ecology); Environmental health; Antiretroviral therapy; Biology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005922999,0.0002005289,0.000608796,0.00009575139,0.000144793,0.00002120629,0.0001640132,0.00004127103,0.000006474049],"category_scores_gemma":[0.00003223747,0.0001313418,0.00002869673,0.00135679,0.00002742466,0.00004683352,0.00007150645,0.0002763595,0.000007597919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001003318,"about_ca_system_score_gemma":0.000632697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002831534,"about_ca_topic_score_gemma":0.01074266,"domain_scores_codex":[0.9981399,0.0001788496,0.0003928852,0.0003710389,0.0003022195,0.0006150909],"domain_scores_gemma":[0.9993048,0.00007484351,0.00009285424,0.0003990207,0.00003494548,0.0000935067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001015124,0.0005254936,0.9611676,0.0002478395,0.00007929726,0.00007868015,0.03452867,0.0009999321,4.433572e-7,0.0003324233,0.0009234067,0.0001010342],"study_design_scores_gemma":[0.005533366,0.0001002843,0.9829837,0.002431029,0.00004067416,0.000004487539,0.006085031,0.002074807,0.000001086337,0.0002458619,0.0003702812,0.0001293992],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790545,0.00136675,0.0003762032,0.01141974,0.00004818428,0.001369515,0.00003590318,0.0001018215,0.006227398],"genre_scores_gemma":[0.992779,0.0001590871,0.001493701,0.0002267427,0.00006220893,0.0001097157,0.0000104459,0.00001004952,0.005149063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02844363,"threshold_uncertainty_score":0.5994655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01738466737035009,"score_gpt":0.2896564506497855,"score_spread":0.2722717832794354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}