{"id":"W4408939564","doi":"10.3390/curroncol32040198","title":"Pathogenesis, Diagnosis, and Management of Cytokine Release Syndrome in Patients with Cancer: Focus on Infectious Disease Considerations","year":2025,"lang":"en","type":"review","venue":"Current Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Medicine; Pathogenesis; Disease; Cytokine; Cancer; Intensive care medicine; Immunology; Bioinformatics; Cytokine release syndrome; Infectious disease (medical specialty); Pathology; Internal medicine; Coronavirus disease 2019 (COVID-19); Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001311334,0.0004114967,0.001026891,0.002335422,0.0002589932,0.000890441,0.0004341642,0.000967485,0.0009453101],"category_scores_gemma":[0.00437456,0.0001571212,0.0008248197,0.001909174,0.0004439479,0.001295671,0.0004514077,0.0006925127,0.0001667162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006999692,"about_ca_system_score_gemma":0.00145658,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001234793,"about_ca_topic_score_gemma":0.001675915,"domain_scores_codex":[0.9991353,0.0003018347,0.0002490017,0.00009980513,0.0001658533,0.00004819638],"domain_scores_gemma":[0.9966025,0.002209384,0.0007123099,0.00003930166,0.0003669945,0.00006941486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004649954,0.00009272012,0.03103828,0.1587956,0.001103523,0.0039392,0.0006953999,0.0005610161,0.002001897,0.003621386,0.02179947,0.7758865],"study_design_scores_gemma":[0.0002387186,0.0009147546,0.09111598,0.3596702,0.005138382,0.06901121,0.003421252,0.0009196869,0.001917354,0.007786497,0.4596867,0.0001792403],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008406483,0.9978094,0.00007367663,0.0008008131,0.00009829103,0.000006181087,0.00001875879,0.000001814869,0.0003504613],"genre_scores_gemma":[0.02377592,0.9739083,0.000557413,0.0009179667,0.0006465885,0.00002389897,0.00005804057,0.000001681233,0.0001102073],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002335422,"threshold_uncertainty_score":0.00693506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07467834341829367,"score_gpt":0.4168006779541516,"score_spread":0.3421223345358579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}