{"id":"W4408956857","doi":"10.1093/jac/dkaf100","title":"Quantitative performance of humanized plasma and epithelial lining fluid exposures of meropenem, cefiderocol and tobramycin against a challenge set of <i>Klebsiella pneumoniae</i> and <i>Pseudomonas aeruginosa</i> in a standardized neutropenic murine pneumonia model","year":2025,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; Bundesministerium für Bildung und Forschung; Novo Nordisk; Public Health Agency; Public Health Agency of Canada; Department of Health and Social Care; Wellcome Trust; National Institutes of Health; U.S. Department of Health and Human Services; Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator; Bill and Melinda Gates Foundation; Novo Nordisk Fonden; Administration for Strategic Preparedness and Response","keywords":"Tobramycin; Meropenem; Pseudomonas aeruginosa; Klebsiella pneumoniae; Microbiology; Klebsiella pneumonia; Antibiotics; Biology; Pneumonia; Cephalosporin; Bacteria; Gentamicin; Medicine; Escherichia coli; Antibiotic resistance; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006345559,0.0003965699,0.0002751427,0.000152401,0.0000807134,0.0002969602,0.0002513264,0.0003425001,0.0008991238],"category_scores_gemma":[0.0006932443,0.0001482128,0.000239969,0.0001451947,0.0002239553,0.000203112,0.0002210291,0.0003701829,0.0001734641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001894933,"about_ca_system_score_gemma":0.0002301413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005592489,"about_ca_topic_score_gemma":0.0005227478,"domain_scores_codex":[0.9993393,0.0002663728,0.0000655367,0.0001154102,0.0001575826,0.00005572449],"domain_scores_gemma":[0.9995459,0.0001317047,0.0001209352,0.00007181997,0.00008188219,0.00004774014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001917461,0.000466905,0.001710991,0.00008038668,0.00002925153,0.00003282274,0.00007170389,0.001359038,0.9890298,0.00003415147,0.0001105217,0.0051569],"study_design_scores_gemma":[0.00005782363,0.0225544,0.008955969,0.000009357785,0.00004216346,0.0001815192,0.00005180969,0.002168832,0.9651691,0.00002678358,0.0007706531,0.00001153605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995609,0.000466569,0.002849204,0.00003413728,0.00001176308,0.00009373327,0.0004778813,0.00003433442,0.0004233616],"genre_scores_gemma":[0.993508,0.0003903482,0.00455307,0.00004336396,0.00001105926,0.00009264353,0.000715605,0.000009470164,0.0006765601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008991238,"threshold_uncertainty_score":0.003355861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01588929730746071,"score_gpt":0.2886008193701756,"score_spread":0.2727115220627149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}