{"id":"W4408957455","doi":"10.1016/j.jacadv.2025.101680","title":"Polygenic Risk Scores in Myocardial Injury After Noncardiac Surgery","year":2025,"lang":"en","type":"article","venue":"JACC Advances","topic":"Cardiac, Anesthesia and Surgical Outcomes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Impact; London Health Sciences Centre; McMaster University; Population Health Research Institute","funders":"Hamilton Health Sciences","keywords":"Medicine; Logistic regression; Perioperative; Cohort; Internal medicine; Stroke (engine); Cardiology; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003109243,0.0006199604,0.0003388163,0.001391644,0.000382312,0.0009556868,0.0004452413,0.000621458,0.002158417],"category_scores_gemma":[0.007787313,0.0002432287,0.001196096,0.001738661,0.0004518502,0.0003593832,0.0008453405,0.0009560958,0.0001913501],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002832456,"about_ca_system_score_gemma":0.0004830557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004630586,"about_ca_topic_score_gemma":0.003542103,"domain_scores_codex":[0.9982273,0.0009357416,0.0001213206,0.0003308634,0.0002243502,0.0001603672],"domain_scores_gemma":[0.9935216,0.00228102,0.002773292,0.0005811993,0.0002892869,0.0005534794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009104512,0.00002517153,0.9962943,0.00001046511,0.0002774595,0.00006134081,0.00002581539,0.0004068081,0.0001051896,0.0001126305,0.0001228534,0.002467037],"study_design_scores_gemma":[0.00000790187,0.00009273217,0.9955479,0.00001197396,0.0001621369,0.000181824,0.00002967615,0.003233279,0.00004753255,0.0005347752,0.0001428685,0.000007431231],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947727,0.0009435106,0.002230043,0.000413438,0.00002687365,0.00002507108,0.0006612609,0.00002844049,0.0008986833],"genre_scores_gemma":[0.9987447,0.0001492095,0.0006134244,0.00003193162,0.00002830418,0.000008847454,0.0003035039,0.000003561447,0.0001164495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004630586,"threshold_uncertainty_score":0.01644349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00446769503924081,"score_gpt":0.2734009511857429,"score_spread":0.268933256146502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}