{"id":"W4408959118","doi":"10.2139/ssrn.5194967","title":"Antibody Responses Against Bacterial Glycans Affinity Mature and Diversify in Germinal Centers","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Germinal center; Glycan; Antibody; Affinity maturation; Chemistry; Cell biology; Biology; Immunology; Molecular biology; Glycoprotein; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002559574,0.0003607606,0.0002353078,0.0002508757,0.0001255761,0.000328999,0.0002798802,0.0004672407,0.004513071],"category_scores_gemma":[0.0002684596,0.0001825066,0.0003105871,0.00013723,0.0001721292,0.0003145525,0.0003294538,0.0007767451,0.001845781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002757774,"about_ca_system_score_gemma":0.00009106618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002598406,"about_ca_topic_score_gemma":0.0002730219,"domain_scores_codex":[0.9998186,0.00002588043,0.000006940485,0.00004539697,0.00003198173,0.00007126658],"domain_scores_gemma":[0.9997815,0.00004621251,0.00003621334,0.00003036118,0.00004559731,0.00005996157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001286089,0.0000142806,0.0002128406,0.00001343308,0.000004312614,0.00002428129,0.000008309426,0.00002796129,0.998152,0.0001096113,0.00005245038,0.001251935],"study_design_scores_gemma":[0.00001666563,0.0002240091,0.006822074,0.000004596017,0.00001268693,0.0001898407,0.00003187626,0.0005345661,0.9904435,0.0001388542,0.001577646,0.00000375494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911094,0.0006155178,0.003804322,0.0001204865,0.00004682061,0.00001716301,0.0001345939,0.00006916859,0.004082676],"genre_scores_gemma":[0.9906248,0.0003123345,0.001668626,0.0002231302,0.00002207951,0.00001111936,0.0004534571,0.0000479118,0.006636478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004513071,"threshold_uncertainty_score":0.0150978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00911205147575803,"score_gpt":0.2994995558956439,"score_spread":0.2903875044198858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}