{"id":"W4408962752","doi":"10.1177/07067437251329073","title":"Polygenic Risk Score Analysis of Antidepressant Treatment Outcomes: A CAN-BIND-1 Study Report: Analyse des résultats du traitement antidépresseur à l’aide des scores de risque polygéniques : Rapport sur l’étude CAN-BIND-1","year":2025,"lang":"en","type":"article","venue":"The Canadian Journal of Psychiatry","topic":"Treatment of Major Depression","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Douglas Mental Health University Institute; University of British Columbia; McGill University; Simon Fraser University; St. Joseph’s Healthcare Hamilton; Royal Ottawa Mental Health Centre; University of Calgary; McMaster University; Queen's University; Centre for Addiction and Mental Health; University of Guelph; Dalhousie University; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Lundbeck Canada; Ontario Brain Institute; Servier Canada","keywords":"Polygenic risk score; Psychology; Gynecology; Antidepressant; Medicine; Psychiatry; Biology; Genetics; Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004807895,0.0009690163,0.0009034963,0.0008087064,0.0005654492,0.001114294,0.001039411,0.0008468953,0.001884095],"category_scores_gemma":[0.009248341,0.000408696,0.001504264,0.00182838,0.0004968882,0.0003894334,0.0009706106,0.000652703,0.0001998632],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007303134,"about_ca_system_score_gemma":0.0009473811,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04647661,"about_ca_topic_score_gemma":0.04832101,"domain_scores_codex":[0.9969473,0.001511915,0.0001467328,0.0006733521,0.0005317657,0.0001888969],"domain_scores_gemma":[0.9935424,0.002516058,0.001539518,0.001355375,0.0006701343,0.0003764982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002316904,0.00005893772,0.9840813,0.00009827306,0.003770588,0.00006633798,0.0001058418,0.0005939604,0.0005515419,0.0001155691,0.0007309043,0.007509899],"study_design_scores_gemma":[0.0002169394,0.0002509531,0.9958038,0.00001487952,0.001121219,0.0001444372,0.00003727766,0.001402019,0.0001159257,0.0001109415,0.000762116,0.00001951488],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990176,0.002056191,0.001837055,0.000206803,0.00002849102,0.00006613743,0.004819684,0.00004006437,0.0007696043],"genre_scores_gemma":[0.9942485,0.0003570125,0.001272454,0.00009296359,0.00004484258,0.00007587003,0.003432645,0.00001760014,0.000458121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9535234,"threshold_uncertainty_score":0.09241217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03705462978164938,"score_gpt":0.3055633375843119,"score_spread":0.2685087078026626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}