{"id":"W4408977370","doi":"10.1016/j.ajhg.2025.03.001","title":"Interplay and cooperation between GLI2 and master transcription factors promote progression of esophageal squamous cell carcinoma","year":2025,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Esophageal squamous cell carcinoma; GLI2; Cancer research; Transcription factor; Basal cell; Oncology; Carcinoma; Medicine; Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001514246,0.0001041516,0.0001804294,0.00006990285,0.00007081258,0.00001940447,0.00009757461,0.00004627421,0.000002023441],"category_scores_gemma":[0.00000701473,0.00007518174,0.00004521384,0.00007830738,0.0002381395,0.000004914965,0.00003860528,0.00009682382,5.739322e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001430409,"about_ca_system_score_gemma":0.00004511782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006667869,"about_ca_topic_score_gemma":0.000007262137,"domain_scores_codex":[0.9992914,0.00009845565,0.0003034952,0.0001147809,0.00009942536,0.00009242816],"domain_scores_gemma":[0.9993871,0.00001140234,0.0003223031,0.0001279058,0.0001119736,0.00003925592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001358847,0.00002509552,0.06546156,0.00002967068,0.00003290496,5.60513e-7,0.0006170518,0.000122042,0.9120526,0.000004366427,0.00004707588,0.02147119],"study_design_scores_gemma":[0.000686795,0.002775134,0.2604235,0.00003582351,0.0001458933,0.0000150188,0.0002551791,0.0001182235,0.7352368,0.00004873276,0.0001675853,0.00009128445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961161,0.002216051,0.001357804,0.00008599711,0.00005334009,0.0001404933,0.000005874714,0.000001600078,0.00002276589],"genre_scores_gemma":[0.9994442,0.00009089623,0.0002675643,0.00001787241,0.00009749169,0.000001057426,0.00001181487,0.0000105073,0.00005862905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1949619,"threshold_uncertainty_score":0.3065822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00909382361991578,"score_gpt":0.2733178316008637,"score_spread":0.2642240079809479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}