{"id":"W4408977370","doi":"10.1016/j.ajhg.2025.03.001","title":"Interplay and cooperation between GLI2 and master transcription factors promote progression of esophageal squamous cell carcinoma","year":2025,"lang":"en","type":"article","venue":"The American Journal of Human Genetics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"Basic and Applied Basic Research Foundation of Guangdong Province; National Natural Science Foundation of China","keywords":"Esophageal squamous cell carcinoma; GLI2; Cancer research; Transcription factor; Basal cell; Oncology; Carcinoma; Medicine; Internal medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645295,0.000192784,0.0002289909,0.0003104379,0.0002070065,0.0003855151,0.0001468198,0.0001476331,0.001130882],"category_scores_gemma":[0.0001558796,0.0001692093,0.0001723972,0.0001739026,0.0001775857,0.0002140144,0.000452362,0.0002972613,0.0002494241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003634899,"about_ca_system_score_gemma":0.0003403899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009053443,"about_ca_topic_score_gemma":0.001667951,"domain_scores_codex":[0.9998986,0.00001832754,0.000005237144,0.00001526246,0.00002487499,0.000037749],"domain_scores_gemma":[0.9999303,0.000006604248,0.00001400766,0.00000845041,0.000008373941,0.00003225483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008689087,0.00006677907,0.0213771,0.00006338023,0.00003329968,0.0004101834,0.00006497391,0.0003857423,0.971238,0.0008301502,0.0005195296,0.004141812],"study_design_scores_gemma":[0.0001285235,0.0003672099,0.4311855,0.00001527057,0.0001101022,0.001077005,0.0006057346,0.008411814,0.5487961,0.0009068507,0.008373655,0.00002238583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969489,0.0009481762,0.0004677025,0.0000998711,0.00001140461,0.000007483414,0.000106629,0.00004681548,0.001363088],"genre_scores_gemma":[0.9986778,0.0001978738,0.0001944465,0.00001806071,0.000005259246,0.000007273225,0.00008337884,0.000005840016,0.000810005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130882,"threshold_uncertainty_score":0.003783166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00909382361991578,"score_gpt":0.2733178316008637,"score_spread":0.2642240079809479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}