{"id":"W4408977958","doi":"10.1016/j.mad.2025.112054","title":"The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice","year":2025,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie Medical Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Androgen receptor; Androgen; Senescence; Gerontology; Ageing; Endocrinology; Internal medicine; Biology; Psychology; Developmental psychology; Medicine; Prostate cancer; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000412517,0.0001711525,0.0003756902,0.0001381228,0.0001994937,0.00001182737,0.00004027614,0.00006521922,0.000004409441],"category_scores_gemma":[0.00008091125,0.0001066124,0.0000348982,0.0001724309,0.00008229873,0.0000336088,0.0001044673,0.0001257855,4.387221e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007017767,"about_ca_system_score_gemma":0.0001272617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001129402,"about_ca_topic_score_gemma":0.00002647588,"domain_scores_codex":[0.9990039,0.0000382231,0.0002722479,0.0003268672,0.0001609572,0.0001978257],"domain_scores_gemma":[0.9995492,0.0001059773,0.000085906,0.000108798,0.00009399347,0.00005612746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002307724,0.0008031829,0.0239978,0.001236748,0.002381674,0.00007280958,0.02142419,0.00004868272,0.7961178,0.02080923,0.0002586092,0.1305415],"study_design_scores_gemma":[0.002223105,0.0008871301,0.5896273,0.0008696419,0.00005853507,0.00002874394,0.006494041,0.0001243321,0.3867301,0.01261664,0.00009240131,0.0002479886],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947166,0.001381452,0.002771475,0.0002522353,0.00004862444,0.0004189349,0.000004100362,0.00001116186,0.0003953502],"genre_scores_gemma":[0.9926112,0.0002915387,0.006597769,0.00003735677,0.000006775825,0.00002415383,0.000002082646,0.0000094371,0.0004197445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5656295,"threshold_uncertainty_score":0.4347529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723579683855093,"score_gpt":0.2967224103298128,"score_spread":0.2694866134912619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}