{"id":"W4408977958","doi":"10.1016/j.mad.2025.112054","title":"The impact of a selective androgen receptor modulator (RAD140) on frailty and underlying mechanisms in older male and female C57Bl/6 mice","year":2025,"lang":"en","type":"article","venue":"Mechanisms of Ageing and Development","topic":"Hormonal and reproductive studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie Medical Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Androgen receptor; Androgen; Senescence; Gerontology; Ageing; Endocrinology; Internal medicine; Biology; Psychology; Developmental psychology; Medicine; Prostate cancer; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003320106,0.0006853763,0.0006525795,0.0006163101,0.0001818055,0.0003174576,0.0003990255,0.0004898419,0.00216003],"category_scores_gemma":[0.0001440647,0.0002129787,0.000540743,0.0001987134,0.000351825,0.0003034513,0.0002199899,0.001036649,0.0004066532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002255961,"about_ca_system_score_gemma":0.0002530251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005729052,"about_ca_topic_score_gemma":0.001249669,"domain_scores_codex":[0.9997569,0.00002573211,0.00002118762,0.00005880743,0.00006787509,0.00006943542],"domain_scores_gemma":[0.9997192,0.0000201792,0.0001052045,0.00002431389,0.00002608291,0.0001049844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00439324,0.0009161704,0.0008114571,0.0001618353,0.00004019391,0.00008769159,0.0000432311,0.0001320134,0.9853445,0.0000747059,0.0001486474,0.007846378],"study_design_scores_gemma":[0.0009890401,0.05343117,0.04116599,0.00008569356,0.0003925675,0.0005708746,0.0001726178,0.000767253,0.8976808,0.0001141561,0.004592101,0.00003787804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952238,0.002415178,0.0005718294,0.0001212948,0.00004577668,0.00004122344,0.0007520216,0.00007526727,0.0007535817],"genre_scores_gemma":[0.9867796,0.003065391,0.001771574,0.0002335852,0.0000634267,0.0001539354,0.001450477,0.00004510031,0.006436909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00216003,"threshold_uncertainty_score":0.00722605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02723579683855093,"score_gpt":0.2967224103298128,"score_spread":0.2694866134912619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}