{"id":"W4408979329","doi":"10.1016/s1556-0864(25)00291-6","title":"96P: Enhanced anti-tumor activity of zelenectide pevedotin in patients (pts) with non-small cell lung cancer (NSCLC) with NECTIN4 gene amplification (amp)","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of Texas MD Anderson Cancer Center; EMD Serono; Sierra Oncology; European Society for Medical Oncology; Seagen; Pfizer; Moderna; Ipsen; Cholangiocarcinoma Foundation; BeiGene; Tizona Therapeutics; Astellas Pharma; Mereo BioPharma; Celldex Therapeutics; National Institutes of Health; Regeneron Pharmaceuticals; Daiichi Sankyo Europe; Gilead Sciences; Foghorn Therapeutics; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; American Society of Clinical Oncology; Merck KGaA; Exelixis; Sanofi; Amgen; G1 Therapeutics; Celgene","keywords":"Medicine; Lung cancer; Oncology; Cancer research; Gene; Internal medicine; Gene duplication; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002460486,0.0001986554,0.0005460504,0.0001186821,0.00007603356,0.00001423448,0.0003108502,0.0001542766,0.00009859168],"category_scores_gemma":[0.00006225365,0.0001648114,0.00008032693,0.0004310674,0.00008205655,0.0001050681,0.000049732,0.0005542022,0.000001216452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004771443,"about_ca_system_score_gemma":0.0007850358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000944936,"about_ca_topic_score_gemma":0.0002635729,"domain_scores_codex":[0.9986483,0.00005127491,0.0005734115,0.0002810982,0.0001941245,0.0002517579],"domain_scores_gemma":[0.9976553,0.0002338028,0.001268744,0.0003314047,0.0004248347,0.00008594428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001732047,0.001383793,0.08937614,0.0004374021,0.00009836928,0.000007879155,0.0002243677,0.0009471937,0.8950476,0.000002401474,0.0001416983,0.01060112],"study_design_scores_gemma":[0.001518296,0.0001587921,0.04454926,0.0003730388,0.0001874879,0.00001679368,0.0001459896,0.00008559477,0.9521733,0.00001595548,0.0006207639,0.0001547579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922146,0.0000727124,0.003331832,0.0003282133,0.00006791989,0.0001688881,0.00002061918,0.00001091493,0.003784303],"genre_scores_gemma":[0.9967842,0.00004988418,0.002357093,0.00005131659,0.0001011787,0.00005258407,0.000009700584,0.00001906361,0.0005750302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05712567,"threshold_uncertainty_score":0.6720816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136426323168211,"score_gpt":0.342964824284787,"score_spread":0.3316005610531049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}