{"id":"W4408979329","doi":"10.1016/s1556-0864(25)00291-6","title":"96P: Enhanced anti-tumor activity of zelenectide pevedotin in patients (pts) with non-small cell lung cancer (NSCLC) with NECTIN4 gene amplification (amp)","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of Texas MD Anderson Cancer Center; EMD Serono; Sierra Oncology; European Society for Medical Oncology; Seagen; Pfizer; Moderna; Ipsen; Cholangiocarcinoma Foundation; BeiGene; Tizona Therapeutics; Astellas Pharma; Mereo BioPharma; Celldex Therapeutics; National Institutes of Health; Regeneron Pharmaceuticals; Daiichi Sankyo Europe; Gilead Sciences; Foghorn Therapeutics; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; American Society of Clinical Oncology; Merck KGaA; Exelixis; Sanofi; Amgen; G1 Therapeutics; Celgene","keywords":"Medicine; Lung cancer; Oncology; Cancer research; Gene; Internal medicine; Gene duplication; Genetics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507092,0.0001930563,0.0003587927,0.0001283057,0.00007981026,0.0002215087,0.0001283267,0.000229959,0.002149957],"category_scores_gemma":[0.0002031078,0.00008954433,0.0002455628,0.0001250719,0.0001268537,0.0002062295,0.0001553087,0.0005263178,0.0003632965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001630016,"about_ca_system_score_gemma":0.0001501833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002160345,"about_ca_topic_score_gemma":0.0003640082,"domain_scores_codex":[0.9999365,0.00001433145,0.000004285685,0.00001827615,0.00001249947,0.00001413129],"domain_scores_gemma":[0.9999532,0.000009261252,0.000008284001,0.000003424648,0.000004302333,0.00002167303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1508855,0.007228844,0.1075309,0.0006643347,0.0008016938,0.002258188,0.0002191963,0.001224914,0.4478709,0.0002818197,0.002959938,0.2780738],"study_design_scores_gemma":[0.02070043,0.2353846,0.4827982,0.00008489662,0.001815374,0.009030371,0.0003268385,0.004821744,0.225315,0.0003586416,0.01926656,0.00009731626],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980397,0.0008424995,0.0001240725,0.00006832226,0.00002445824,0.00002747274,0.000184902,0.000020115,0.000668371],"genre_scores_gemma":[0.9984838,0.000317414,0.0001552816,0.00005519312,0.000009403258,0.0000164175,0.0002496793,0.000002153489,0.0007106716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002149957,"threshold_uncertainty_score":0.007192373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01136426323168211,"score_gpt":0.342964824284787,"score_spread":0.3316005610531049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}