{"id":"W4408980834","doi":"10.1016/s1556-0864(25)00386-7","title":"192P: Differential effect of proton pump inhibitors (PPIs) and antibiotics (ATB) on clinical outcomes from immunotherapy or placebo in patients with locally advanced, unresectable NSCLC who have not progressed following chemoradiation therapy (cCTRT): A post-hoc analysis of the PACIFIC trial","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Placebo; Immunotherapy; Internal medicine; Oncology; Antibiotics; Chemoradiotherapy; Chemotherapy; Cancer; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002229063,0.002206789,0.004683158,0.0003264112,0.0003508451,0.001229907,0.0008774461,0.001156939,0.005600351],"category_scores_gemma":[0.002816793,0.0006358793,0.004574466,0.0003672771,0.001361987,0.001589165,0.0007515763,0.004489143,0.000716186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007302354,"about_ca_system_score_gemma":0.001097571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009944703,"about_ca_topic_score_gemma":0.001778557,"domain_scores_codex":[0.9988229,0.000703417,0.00005441059,0.0002019733,0.00005391956,0.0001634054],"domain_scores_gemma":[0.998645,0.0006627814,0.0002286928,0.000142767,0.00006746814,0.0002532768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9887801,0.0008248065,0.000671936,0.0002416425,0.002450129,0.00002018954,0.00002185111,0.0002638641,0.001437485,0.0000596984,0.0003366526,0.00489168],"study_design_scores_gemma":[0.7990997,0.1777191,0.01084299,0.00005906221,0.00799761,0.00008329965,0.00008057357,0.0009835806,0.001445781,0.0005286097,0.001106843,0.00005302084],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935522,0.002047666,0.0004387389,0.0005262061,0.0003687764,0.0006415606,0.001138215,0.00006755248,0.00121914],"genre_scores_gemma":[0.9929118,0.001101622,0.0008487176,0.0004664371,0.0004202799,0.0009720161,0.001120634,0.00003432903,0.002124145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005600351,"threshold_uncertainty_score":0.01873505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471447977675807,"score_gpt":0.3835884075308421,"score_spread":0.3688739277540841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}