{"id":"W4408981555","doi":"10.1016/s1556-0864(25)00491-5","title":"299P: First-line (1L) durvalumab (D) + platinum-etoposide (EP) in extensive-stage SCLC (ES-SCLC): Final results and exploratory biomarker analyses from LUMINANCE","year":2025,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Durvalumab; Etoposide; Oncology; Biomarker; Stage (stratigraphy); Internal medicine; Cancer; Nivolumab; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001638429,0.0003039686,0.001337186,0.0007095655,0.0001812015,0.00003489294,0.0002616511,0.0002448695,0.00006255943],"category_scores_gemma":[0.003426427,0.0002408296,0.0001924366,0.0007710986,0.0005220168,0.0002948718,0.000283404,0.0009298907,0.000009343761],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009179626,"about_ca_system_score_gemma":0.001136567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002900784,"about_ca_topic_score_gemma":0.001554814,"domain_scores_codex":[0.9966893,0.0004736223,0.001317252,0.0004626309,0.0005580045,0.0004992521],"domain_scores_gemma":[0.9964034,0.0014471,0.0007718656,0.0004081938,0.0007462729,0.0002231495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1293721,0.003184423,0.1348222,0.002211605,0.00483713,0.0332276,0.00739826,0.0007321423,0.07797135,0.0001115323,0.1158296,0.4903021],"study_design_scores_gemma":[0.01559323,0.004519731,0.8750621,0.004667902,0.001076414,0.0004906822,0.00425074,0.001658622,0.01419118,0.0009834835,0.07699797,0.0005079424],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622663,0.01767795,0.0003051093,0.01644809,0.0007445481,0.0004154193,0.00008388409,0.0000217374,0.002036928],"genre_scores_gemma":[0.9867748,0.005155589,0.004196937,0.0008666837,0.0003753433,0.00002489382,0.0000154017,0.00002631509,0.002564027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7402399,"threshold_uncertainty_score":0.9820747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1280930871144411,"score_gpt":0.5083823957932491,"score_spread":0.3802893086788079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}