{"id":"W4408985065","doi":"10.1016/j.clml.2025.03.014","title":"Outcomes of Patients With Extramedullary Disease in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma From the Pooled LocoMMotion and MoMMent Studies","year":2025,"lang":"en","type":"article","venue":"Clinical Lymphoma Myeloma & Leukemia","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"Legend Biotech; Johnson and Johnson","keywords":"Medicine; Multiple myeloma; Refractory (planetary science); Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000626579,0.0004800607,0.001286768,0.0002118819,0.0001684459,0.00003455947,0.0003088486,0.0002493817,0.00003104704],"category_scores_gemma":[0.004185154,0.0002896154,0.0002895242,0.0004413085,0.0007970576,0.000173864,0.0003297006,0.0004007266,0.00001593121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009104401,"about_ca_system_score_gemma":0.0008613139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003499361,"about_ca_topic_score_gemma":0.00022113,"domain_scores_codex":[0.9958559,0.0005965682,0.00141211,0.0008297593,0.0007435582,0.0005620905],"domain_scores_gemma":[0.9929666,0.004834912,0.0003701767,0.001033113,0.0003292967,0.0004659127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007590243,0.001244145,0.7642829,0.0001073136,0.001095168,0.0001517172,0.0001974092,0.000003667568,0.00003364832,0.00003540882,0.0004581883,0.2248002],"study_design_scores_gemma":[0.03682359,0.0007862451,0.9587267,0.0007065404,0.000453059,9.055528e-7,0.0004037049,0.0006671624,0.0001542721,0.0002697887,0.0007721694,0.0002358611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922399,0.002608696,0.00003308418,0.002421618,0.0003119502,0.002029722,0.0001807701,0.00006411726,0.0001101703],"genre_scores_gemma":[0.9967914,0.0005796901,0.0005154764,0.001144619,0.00007388844,0.0002141592,0.0003213454,0.00004349395,0.0003158876],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2245643,"threshold_uncertainty_score":0.9999556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03591341014526184,"score_gpt":0.3351751832576492,"score_spread":0.2992617731123874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}