{"id":"W4408986880","doi":"10.1016/j.ijrobp.2025.03.043","title":"Comprehensive Molecular Analysis in NRG Oncology/RTOG 9813: A Phase 3 Study of Radiation and Temozolomide Versus Radiation and BCNU/CCNU in Anaplastic Astrocytoma","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Ohio State University; National Cancer Institute; Brain Tumor Funders' Collaborative; Merck","keywords":"Temozolomide; Medicine; Oncology; Anaplastic astrocytoma; Radiation therapy; Internal medicine; Lomustine; Radiation oncology; Glioblastoma; Astrocytoma; Cancer research; Chemotherapy; Vincristine; Cyclophosphamide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002253417,0.001293278,0.002729538,0.0008469232,0.0005362909,0.001098037,0.00122444,0.0008092595,0.002323642],"category_scores_gemma":[0.0007322793,0.0008226203,0.001846203,0.001363564,0.001034456,0.0007508998,0.0004294147,0.001763477,0.0005114838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001588395,"about_ca_system_score_gemma":0.002736068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003838618,"about_ca_topic_score_gemma":0.01142405,"domain_scores_codex":[0.99935,0.0002876743,0.00003099469,0.0001120165,0.0001122411,0.0001071167],"domain_scores_gemma":[0.9995167,0.00008758371,0.0001293184,0.00006233663,0.00004277773,0.0001612473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.525345,0.04152699,0.03983226,0.0009973003,0.006098186,0.0002275796,0.0005663577,0.01392796,0.1982105,0.0004531411,0.00355533,0.1692594],"study_design_scores_gemma":[0.2140886,0.5305873,0.1963212,0.0001008023,0.0100224,0.00113576,0.0003924496,0.008150677,0.03021324,0.0007712702,0.008065274,0.0001511838],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973419,0.001048701,0.0002279331,0.0001145555,0.00002068862,0.0002952705,0.0005547256,0.00003570605,0.0003604779],"genre_scores_gemma":[0.9911186,0.001998314,0.001850614,0.0002729784,0.00003738735,0.000704285,0.002920151,0.00007004916,0.001027564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003838618,"threshold_uncertainty_score":0.01191735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199553699405063,"score_gpt":0.3692857553735334,"score_spread":0.3493303854330271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}