{"id":"W4408987622","doi":"10.1038/s41419-025-07547-7","title":"A novel clinically relevant antagonistic interplay between prolactin and oncogenic YAP-CCN2 pathways as a differentiation therapeutic target in breast cancer","year":2025,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"CIHR Skin Research Training Centre; Government of Canada","keywords":"Hippo signaling pathway; Biology; Cancer research; CD44; Breast cancer; Cancer; Cancer stem cell; Cancer cell; Cell biology; Cellular differentiation; Stem cell marker; Stem cell; Signal transduction; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002769246,0.0001970458,0.0003003771,0.0002904914,0.0001568389,0.000443476,0.0001389642,0.0001570559,0.0005357315],"category_scores_gemma":[0.0003002431,0.0001011448,0.0002415078,0.0003697503,0.0001273096,0.0001471852,0.0002432252,0.0003544319,0.0001279894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004999283,"about_ca_system_score_gemma":0.0006316791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009284441,"about_ca_topic_score_gemma":0.002539853,"domain_scores_codex":[0.9998054,0.00003259118,0.00001162088,0.0000504759,0.00006822684,0.00003174674],"domain_scores_gemma":[0.9999058,0.0000193651,0.00003373718,0.000007741854,0.00001343356,0.00001986558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001873997,0.0001238384,0.03134434,0.0006597112,0.0002036753,0.0008215141,0.00008105571,0.003233055,0.8742243,0.0008724667,0.00278838,0.0837737],"study_design_scores_gemma":[0.0003447729,0.001827456,0.2502143,0.0001082742,0.0008922561,0.008360304,0.0003468196,0.03955296,0.6171691,0.002481681,0.07860798,0.00009402871],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751628,0.01182564,0.0059491,0.0009597837,0.00004947424,0.00005674452,0.003022443,0.0002887642,0.0026851],"genre_scores_gemma":[0.9892559,0.002876438,0.003911487,0.0001874651,0.00002050166,0.00003675662,0.003130116,0.00001993675,0.0005612993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009284441,"threshold_uncertainty_score":0.0036273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01213744295615916,"score_gpt":0.2879411941007853,"score_spread":0.2758037511446261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}