{"id":"W4408992980","doi":"10.1002/iub.70017","title":"Yeast models for Charcot‐Marie‐Tooth disease‐causing aminoacyl‐ <scp>tRNA</scp> synthetase alleles reveal the cellular basis of disease","year":2025,"lang":"en","type":"review","venue":"IUBMB Life","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Allele; Yeast; Tooth disease; Disease; Aminoacyl tRNA synthetase; Biology; Genetics; Saccharomyces cerevisiae; Transfer RNA; Microbiology; Gene; Medicine; RNA; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005598953,0.001001123,0.002026871,0.0003021266,0.0004417657,0.0001532102,0.001761681,0.0003139904,0.00005030028],"category_scores_gemma":[0.01843386,0.0006948054,0.001610145,0.0008520423,0.0006802729,0.000298757,0.0006533734,0.0007057059,0.00004640937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007470588,"about_ca_system_score_gemma":0.00137215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001717706,"about_ca_topic_score_gemma":0.00000279661,"domain_scores_codex":[0.9936252,0.001337477,0.001337418,0.001673074,0.0009679376,0.001058922],"domain_scores_gemma":[0.9899574,0.006426381,0.0007894364,0.00173167,0.0001094712,0.0009856384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006333722,0.003989686,0.00005377302,0.1956305,0.000905887,0.001553293,0.000401881,0.005423578,0.0005227518,0.02607653,0.09070974,0.674099],"study_design_scores_gemma":[0.0004803945,0.0001205374,0.00001984675,0.005241054,0.002522687,0.000003240489,0.00003102308,0.003508613,0.0001146371,0.003242425,0.984199,0.0005165461],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004156601,0.9804355,0.002049242,0.0006891437,0.0008171913,0.004498878,0.009956711,0.0002201417,0.0009175391],"genre_scores_gemma":[0.007237223,0.9866128,0.00008129232,0.002470339,0.0005131136,0.001064045,0.0003042068,0.0001826788,0.001534281],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8934892,"threshold_uncertainty_score":0.9995503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08978397880243857,"score_gpt":0.3055848530806925,"score_spread":0.2158008742782539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}