{"id":"W4408995533","doi":"10.3390/cells14070505","title":"Preclinical Models for Studying Fuchs Endothelial Corneal Dystrophy","year":2025,"lang":"en","type":"review","venue":"Cells","topic":"Corneal surgery and disorders","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"National Medical Research Council; Natural Sciences and Engineering Research Council of Canada","keywords":"Regenerative medicine; Extracellular matrix; Biology; Disease; Transplantation; In vivo; Endothelial stem cell; Medicine; Bioinformatics; Pathology; Neuroscience; Stem cell; Cell biology; Genetics; In vitro; Surgery","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009195958,0.0008429466,0.001144396,0.001778425,0.0002836326,0.000850577,0.0008019285,0.001187972,0.002716561],"category_scores_gemma":[0.0006132924,0.0002410146,0.0005536059,0.0008855829,0.0004763349,0.0007739835,0.0006113141,0.002010131,0.001294071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004781297,"about_ca_system_score_gemma":0.000764182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006845167,"about_ca_topic_score_gemma":0.001232249,"domain_scores_codex":[0.9996822,0.00006287562,0.00004124385,0.00004358217,0.0001350175,0.00003512642],"domain_scores_gemma":[0.9996712,0.0001280489,0.00005454178,0.00002062184,0.00008858115,0.00003696142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003935053,0.0006786791,0.0008217705,0.03089434,0.0002671075,0.001148159,0.0001804184,0.0009056112,0.1462469,0.01631602,0.03047859,0.7716689],"study_design_scores_gemma":[0.00008951624,0.001376502,0.002187037,0.003822636,0.0004408296,0.004466964,0.0001308002,0.0003739457,0.03741566,0.00369719,0.9459392,0.00005969895],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003192664,0.984436,0.003230161,0.0004686626,0.0005789538,0.0001285319,0.0003193108,0.00007625281,0.007569478],"genre_scores_gemma":[0.01323579,0.9784117,0.003851635,0.0004972026,0.0001922298,0.0002204249,0.0006811669,0.00001531494,0.002894595],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002716561,"threshold_uncertainty_score":0.009087861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1433118659599,"score_gpt":0.3894550071709469,"score_spread":0.2461431412110469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}