{"id":"W4408999963","doi":"10.3390/curroncol32040201","title":"Combined Use of Gefitinib and Bevacizumab in Advanced Non-Small-Cell Lung Cancer with EGFR G719S/S768I Mutations and Acquired C797S Without T790M After Osimertinib: A Case Report and Literature Review","year":2025,"lang":"en","type":"review","venue":"Current Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China","keywords":"Osimertinib; Gefitinib; Medicine; T790M; Bevacizumab; Lung cancer; Epidermal growth factor receptor; Oncology; Cancer research; Targeted therapy; Internal medicine; Cancer; Erlotinib; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004199701,0.0005919585,0.001383073,0.002558356,0.0002557654,0.0006145331,0.0009129299,0.0008381627,0.002007044],"category_scores_gemma":[0.0005684879,0.0002148904,0.0007402442,0.002246309,0.000311157,0.001020533,0.0003952688,0.0007897798,0.000742156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004789207,"about_ca_system_score_gemma":0.0007810828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00110302,"about_ca_topic_score_gemma":0.002730313,"domain_scores_codex":[0.9998054,0.00003568667,0.00005080178,0.0000354229,0.00005569203,0.00001708896],"domain_scores_gemma":[0.9997734,0.0001265228,0.0000440054,0.000005791181,0.00003673123,0.00001359173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.0001079444,0.00007415685,0.0004090477,0.04003312,0.0003252215,0.00248284,0.0001055932,0.0002378482,0.001327017,0.0009189229,0.01603261,0.9379458],"study_design_scores_gemma":[0.00008602714,0.0003616204,0.005126022,0.02252263,0.001758732,0.05180222,0.0002843919,0.0002636868,0.001409758,0.001257161,0.9150594,0.00006831707],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002626632,0.9989797,0.0000512918,0.0000908598,0.00007882993,0.000004254748,0.000008266187,0.000002689885,0.0005212612],"genre_scores_gemma":[0.001529089,0.9978853,0.00009691611,0.00014608,0.00008343647,0.000004703323,0.00002131435,0.000001119622,0.0002320776],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002558356,"threshold_uncertainty_score":0.006714225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04802578443562181,"score_gpt":0.4481300859680908,"score_spread":0.400104301532469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}