{"id":"W4409004786","doi":"10.1038/s41569-025-01144-z","title":"Factor XI inhibitors for the prevention and treatment of venous and arterial thromboembolism","year":2025,"lang":"en","type":"review","venue":"Nature Reviews Cardiology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hamilton Health Sciences; University Health Network; St. Michael's Hospital; McMaster University; Canadian VIGOUR Centre; University of Alberta; Population Health Research Institute","funders":"","keywords":"Medicine; Venous thromboembolism; Intensive care medicine; Cardiology; Internal medicine; Thrombosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002638262,0.0003952464,0.004213972,0.0001134675,0.00008547032,0.00001055802,0.00007044742,0.0008464346,0.000008071582],"category_scores_gemma":[0.0002252978,0.0002100588,0.001050082,0.0001368261,0.0001286452,0.00002336158,0.00003625987,0.0002249801,0.00000125881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007123932,"about_ca_system_score_gemma":0.0002911429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005540009,"about_ca_topic_score_gemma":0.000005644084,"domain_scores_codex":[0.9983181,0.0002628285,0.0007145688,0.0004189392,0.00008436174,0.0002012421],"domain_scores_gemma":[0.9984306,0.000631828,0.0004308249,0.0003820368,0.00006479579,0.00005989947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002163357,0.00003293405,0.00002532264,0.01387312,0.0006011042,0.000002182854,0.00006217797,2.091959e-8,0.000002257903,0.000246173,0.0008948471,0.9842382],"study_design_scores_gemma":[0.0006548658,0.00054439,0.0005023305,0.008062809,0.005608845,0.00015258,0.000005832339,5.770372e-7,0.000002937277,0.0001070483,0.9842159,0.000141943],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007316054,0.9935648,0.00003962712,0.00009638604,0.00128841,0.004690638,0.0001368786,0.000015523,0.00009461439],"genre_scores_gemma":[0.0001696285,0.99705,0.000127485,0.0000430325,0.001577539,0.0004200829,0.000260138,0.00002447857,0.0003276555],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9840963,"threshold_uncertainty_score":0.8565952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04677835800784338,"score_gpt":0.3752647849116075,"score_spread":0.3284864269037641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}