{"id":"W4409016230","doi":"10.1016/j.mucimm.2025.03.007","title":"Gut microbiota regulates intestinal goblet cell response and mucin production by influencing the TLR2-SPDEF axis in an enteric parasitic infection","year":2025,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; McMaster University; Cincinnati Children's Hospital Medical Center","keywords":"Goblet cell; Mucin; Microbiology; Mucin 2; Enteric virus; Biology; TLR2; Immunology; Mucosal immunology; Immunity; Epithelium; Genetics; Immune system; Innate immune system; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004291332,0.0001719171,0.0001630197,0.0001323698,0.000160732,0.0000337522,0.0001388158,0.0002094246,0.000007085353],"category_scores_gemma":[0.0001325366,0.0001496347,0.00003210254,0.0002070979,0.0002161144,0.00001152103,0.0001052289,0.0002440724,0.000006392328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006674934,"about_ca_system_score_gemma":0.0001198132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004451635,"about_ca_topic_score_gemma":0.0003797179,"domain_scores_codex":[0.998478,0.0004652702,0.0002778208,0.0004366047,0.00002960169,0.0003127341],"domain_scores_gemma":[0.9994187,0.00003399271,0.00008781438,0.0003649521,0.00006706576,0.00002745539],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006558934,0.0001096002,0.02269132,0.00003604534,0.00001701248,0.000001580153,0.0001924294,0.00001004185,0.9741068,0.000008609304,0.001148608,0.001022065],"study_design_scores_gemma":[0.0005746745,0.0006158136,0.5358726,0.00004587342,0.00001530293,0.0001034376,0.000138595,0.00001281794,0.4571507,0.00004343384,0.005278917,0.0001477744],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995701,0.002304074,0.00006205993,0.001300887,0.0002894309,0.0002837714,0.000005289999,0.00002003373,0.00003349047],"genre_scores_gemma":[0.9983846,0.0003707012,0.0001253633,0.0004207935,0.00003781583,0.0000252436,0.00008562228,0.00001382073,0.0005360218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5169561,"threshold_uncertainty_score":0.6101925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00528477671778305,"score_gpt":0.2526405063107159,"score_spread":0.2473557295929329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}