{"id":"W4409020731","doi":"10.1371/journal.ppat.1012636","title":"VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages","year":2025,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; Biology; Cell biology; Vacuole; Leishmania; Virulence; Amastigote; Phagosome; Lipid droplet; Cytoplasm; Intracellular; Biochemistry; Parasite hosting; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940815,0.0002493694,0.0002259748,0.0001275341,0.0002619295,0.0004132302,0.0002596616,0.000293805,0.0009780173],"category_scores_gemma":[0.0002008388,0.0001225783,0.0002808191,0.00007857189,0.0002150634,0.0003352654,0.0006204364,0.0004060632,0.0004447024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003191829,"about_ca_system_score_gemma":0.0002713998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009717544,"about_ca_topic_score_gemma":0.0008938952,"domain_scores_codex":[0.9997993,0.00004663633,0.00001032207,0.00003453312,0.00004609199,0.0000630031],"domain_scores_gemma":[0.9998848,0.00002310716,0.0000224946,0.00001468815,0.00002539415,0.000029423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001385632,0.00001343937,0.0007600849,0.00006185404,0.000005983137,0.0001312519,0.00003225911,0.00004214549,0.9976101,0.0002082299,0.00003701295,0.0009591409],"study_design_scores_gemma":[0.00004885597,0.0003401849,0.025285,0.00003053592,0.0000405354,0.001030583,0.0003129978,0.006222857,0.9600813,0.0003684128,0.006224821,0.00001388396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936171,0.001747979,0.003025451,0.0001684188,0.00002051657,0.00002021832,0.0002365578,0.0000547839,0.001109002],"genre_scores_gemma":[0.9980072,0.0002973966,0.0007951257,0.00003580617,0.000005108253,0.00001633765,0.0001959848,0.000007874939,0.0006390855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009780173,"threshold_uncertainty_score":0.003271818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03075123497219413,"score_gpt":0.2947219052765283,"score_spread":0.2639706703043342,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}