{"id":"W4409021109","doi":"10.1016/j.jconrel.2025.113675","title":"Enzymatic absorption promoters for non-invasive peptide delivery","year":2025,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Innosuisse - Schweizerische Agentur für Innovationsförderung; European Research Council; Institut national de la recherche scientifique; Vetenskapsrådet; Horizon 2020; Eidgenössische Technische Hochschule Zürich; HORIZON EUROPE European Research Council; Vontobel-Stiftung","keywords":"Peptide; Enzyme; Absorption (acoustics); Chemistry; Biochemistry; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001353373,0.0002430198,0.0008704877,0.000383976,0.0002010358,0.00002718699,0.0002980938,0.000264401,0.0001022256],"category_scores_gemma":[0.00123255,0.0001972597,0.0005642683,0.0001887086,0.0000935417,0.0002592088,0.0000300992,0.0006512366,0.0000408294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002189785,"about_ca_system_score_gemma":0.0005148699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002972704,"about_ca_topic_score_gemma":0.000005895165,"domain_scores_codex":[0.9976551,0.0004263686,0.001164972,0.0001888366,0.0002056641,0.0003590923],"domain_scores_gemma":[0.9955215,0.002260867,0.001040561,0.0001728411,0.0007808575,0.0002233881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.1150751,0.002656518,0.003045009,0.00213982,0.009711992,0.0008962825,0.002639757,0.0638568,0.5425057,0.002507586,0.1730382,0.08192722],"study_design_scores_gemma":[0.3238447,0.003855047,0.001024883,0.002358598,0.00816799,0.0006369838,0.0033036,0.1960052,0.1066407,0.00984806,0.3426803,0.001634034],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9474432,0.003405927,0.03584234,0.002657296,0.004834514,0.003069424,0.00003788977,0.00004473545,0.002664669],"genre_scores_gemma":[0.9911051,0.0004732073,0.001032994,0.001914525,0.0005252773,0.0001109064,0.000004330186,0.000022275,0.004811344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.435865,"threshold_uncertainty_score":0.8044016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926305973932351,"score_gpt":0.3885593706123036,"score_spread":0.3492963108729801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}