{"id":"W4409021109","doi":"10.1016/j.jconrel.2025.113675","title":"Enzymatic absorption promoters for non-invasive peptide delivery","year":2025,"lang":"en","type":"article","venue":"Journal of Controlled Release","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Innosuisse - Schweizerische Agentur für Innovationsförderung; European Research Council; Institut national de la recherche scientifique; Vetenskapsrådet; Horizon 2020; Eidgenössische Technische Hochschule Zürich; HORIZON EUROPE European Research Council; Vontobel-Stiftung","keywords":"Peptide; Enzyme; Absorption (acoustics); Chemistry; Biochemistry; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003989686,0.0004177855,0.0002639944,0.0002186128,0.0001124894,0.0003613812,0.0002166826,0.000379729,0.00100932],"category_scores_gemma":[0.000369211,0.0001965759,0.0002970265,0.0001412605,0.0003249429,0.0004066822,0.0003609383,0.00078936,0.0004323031],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133112,"about_ca_system_score_gemma":0.0002017469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001587492,"about_ca_topic_score_gemma":0.0002180484,"domain_scores_codex":[0.999755,0.00005117929,0.00001868594,0.00004664445,0.000100539,0.00002789643],"domain_scores_gemma":[0.9997502,0.00008909973,0.0001039433,0.00001660409,0.00002393962,0.00001625667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002963885,0.00001963598,0.0000519995,0.0001705779,0.000005786749,0.00005684093,0.00002718916,0.0001086993,0.9938843,0.0005872518,0.00009504714,0.004962972],"study_design_scores_gemma":[0.00001119397,0.000195506,0.0002971672,0.00001528502,0.00001141557,0.0001618026,0.00001212644,0.000990737,0.991438,0.00008760294,0.006773426,0.000005794994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.687012,0.03401732,0.2652239,0.0008538113,0.0002947061,0.000499598,0.0003941783,0.0009327447,0.01077175],"genre_scores_gemma":[0.934638,0.01140857,0.04772313,0.0001614201,0.00006814956,0.0002973109,0.0002276484,0.00008884614,0.005386926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00100932,"threshold_uncertainty_score":0.003376484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03926305973932351,"score_gpt":0.3885593706123036,"score_spread":0.3492963108729801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}