{"id":"W4409039996","doi":"10.1016/j.mcpdig.2025.100217","title":"Quantifying the Unknowns of Plaque Morphology: The Role of Topological Uncertainty in Coronary Artery Disease","year":2025,"lang":"en","type":"article","venue":"Mayo Clinic Proceedings Digital Health","topic":"Cerebrovascular and Carotid Artery Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Daiichi Sankyo Europe; Duke Clinical Research Institute; St. Jude Medical; Pfizer; Moderna; Belvoir Media Group; MyoKardia; Novo Nordisk; Medicines Company; AstraZeneca; Amarin Corporation; Ironwood Pharmaceuticals, Incorporated; Assistance publique-Hôpitaux de Paris; National Institutes of Health; Regeneron Pharmaceuticals; Boston Scientific Corporation; Idorsia Pharmaceuticals; Brigham and Women's Hospital; Bristol-Myers Squibb; Cleveland Clinic; Alnylam Pharmaceuticals; HLS Therapeutics; GlaxoSmithKline; CSL Behring; Eli Lilly and Company; Amgen; Sanofi; American Heart Association","keywords":"Coronary artery disease; Morphology (biology); Cardiology; Vulnerable plaque; Internal medicine; Medicine; Topology (electrical circuits); Artificial intelligence; Mathematics; Computer science; Biology; Combinatorics; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000572376,0.0001612371,0.0004951672,0.00009902059,0.0000911293,0.00002242016,0.0002493437,0.00007037938,0.00005518592],"category_scores_gemma":[0.0004575438,0.0000911236,0.0002738415,0.0003638987,0.0005006657,0.0001091196,0.0001404003,0.0003013116,0.000009526964],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007278093,"about_ca_system_score_gemma":0.0005683962,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006290244,"about_ca_topic_score_gemma":0.00001805762,"domain_scores_codex":[0.9983571,0.00003516094,0.0007317137,0.0003049888,0.0002462758,0.0003247459],"domain_scores_gemma":[0.9989163,0.0003414814,0.0002219689,0.0002572259,0.0001144828,0.0001485738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000596485,0.0006656725,0.9809796,0.0004950907,0.00007620559,0.00000415409,0.0003745536,0.000003534262,0.00004564685,0.005762151,0.000592909,0.01040396],"study_design_scores_gemma":[0.001227437,0.0004550359,0.9843002,0.0005236622,0.00006918629,0.00003189306,0.006687077,0.0002024757,0.00005989485,0.004503894,0.001846838,0.00009238541],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877753,0.001455537,0.000005809183,0.005906267,0.0001096509,0.0008018128,0.00006727915,0.00003369004,0.00384462],"genre_scores_gemma":[0.9975882,0.0003153863,0.000006411789,0.001766211,0.00004458475,0.00004616968,0.00002853581,0.0000102773,0.00019427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01031158,"threshold_uncertainty_score":0.3715912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0306922339347514,"score_gpt":0.3303892542005199,"score_spread":0.2996970202657685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}