{"id":"W4409046068","doi":"10.1093/ecco-jcc/jjaf025","title":"Corticosteroid-sparing effects of risankizumab efficacy and safety in patients with moderately to severely active ulcerative colitis","year":2025,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Genentech; Eisai; Moderna; Celltrion; Astellas Pharma; Mylan; Mayo Foundation for Medical Education and Research; Therakos; Leona M. and Harry B. Helmsley Charitable Trust; AbbVie; Teva Pharmaceutical Industries; Gilead Sciences; Sanofi; Celgene; Biogen; GlaxoSmithKline; Amgen; Dr. Falk Pharma; Pfizer; Celltrion Healthcare; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Corticosteroid; Discontinuation; Ulcerative colitis; Maintenance therapy; Thiopurine methyltransferase; Adverse effect; Placebo; Internal medicine; Population; Gastroenterology; Surgery; Chemotherapy; Inflammatory bowel disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003189481,0.0003113517,0.001238494,0.0001839473,0.0001657239,0.000387596,0.0002450576,0.0002487233,0.001256823],"category_scores_gemma":[0.002582268,0.0001493762,0.001552639,0.000223634,0.000290726,0.0002662361,0.000218952,0.0005835999,0.0001329514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00027128,"about_ca_system_score_gemma":0.0007649306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002777326,"about_ca_topic_score_gemma":0.0009770371,"domain_scores_codex":[0.99876,0.0007839816,0.0001425784,0.0001062639,0.0001178092,0.00008939694],"domain_scores_gemma":[0.9973877,0.001308818,0.000749019,0.0001346136,0.0001438239,0.0002759483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7655762,0.002096378,0.1087805,0.001547168,0.00511881,0.0001402409,0.0001767796,0.001131854,0.01094236,0.0000859756,0.0007409031,0.1036629],"study_design_scores_gemma":[0.1387538,0.3894982,0.4516877,0.0002265223,0.008501192,0.0006138348,0.0001534862,0.002184156,0.004919624,0.0002221711,0.003190053,0.0000492877],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956508,0.003296227,0.0001497539,0.0001240032,0.00001749842,0.0001465304,0.0001782273,0.00001076884,0.0004262385],"genre_scores_gemma":[0.9989905,0.0003491404,0.0002393934,0.00006784551,0.00002652807,0.00005775992,0.00016607,0.000001922248,0.0001007512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003189481,"threshold_uncertainty_score":0.01686776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003453790838176428,"score_gpt":0.222691509594091,"score_spread":0.2192377187559145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}