{"id":"W4409047944","doi":"10.1097/hep.0000000000001334","title":"Getting to HBV cure—Will new biomarkers help?","year":2025,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto Liver Centre; University Health Network","funders":"","keywords":"cccDNA; HBcAg; Medicine; Hepatitis B virus; Hepatitis B; Clinical trial; Immunology; Entecavir; Antigen; Serology; HBsAg; Virology; Lamivudine; Virus; Internal medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001367839,0.000161768,0.0004741566,0.0002755655,0.000102854,0.000008214069,0.0001008798,0.0001306596,0.0002282588],"category_scores_gemma":[0.0007194907,0.0001518944,0.00008228499,0.0004276226,0.00007368432,0.00003749497,0.0001628105,0.000151046,0.0003981035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001153654,"about_ca_system_score_gemma":0.0002739393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00251481,"about_ca_topic_score_gemma":0.002757152,"domain_scores_codex":[0.99874,0.00005768901,0.0003093233,0.0003446547,0.0001184986,0.0004298015],"domain_scores_gemma":[0.9992277,0.0001434459,0.00004306509,0.0003218258,0.00008671497,0.000177235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007446036,0.0000321204,0.749705,0.00006241266,0.0001943301,0.0001373435,0.0002466755,2.051051e-7,0.001783122,0.002328562,0.2177818,0.02765401],"study_design_scores_gemma":[0.001040795,0.0001799856,0.08802563,0.0001679292,0.0001313985,0.00008536177,0.00007721652,0.0002070787,0.003015763,0.000955907,0.9059156,0.0001973253],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7940326,0.004226996,0.003525568,0.1176511,0.001791627,0.0009432767,0.00001129048,0.0003921843,0.07742532],"genre_scores_gemma":[0.9706998,0.0002356867,0.004859407,0.01698371,0.0001652295,0.00004038849,0.000007690645,0.00002181372,0.006986315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6881338,"threshold_uncertainty_score":0.6194075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02135776373530832,"score_gpt":0.3190040071994641,"score_spread":0.2976462434641558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}