{"id":"W4409048370","doi":"10.7554/elife.103718.3","title":"UBR-1 deficiency leads to ivermectin resistance in Caenorhabditis elegans","year":2025,"lang":"en","type":"article","venue":"eLife","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Major International Joint Research Programme; National Natural Science Foundation of China","keywords":"Caenorhabditis elegans; Ivermectin; Biology; Genetics; Caenorhabditis; Cell biology; Gene; Zoology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138663,0.0006446787,0.0003249556,0.0005436785,0.0002656993,0.0002875529,0.0004420474,0.0006418224,0.001423912],"category_scores_gemma":[0.0001422977,0.000277396,0.0003911649,0.0001770712,0.000333119,0.0001737488,0.00033129,0.0008825441,0.0004792614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006722067,"about_ca_system_score_gemma":0.0003238339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003845703,"about_ca_topic_score_gemma":0.007135829,"domain_scores_codex":[0.9997438,0.00001962916,0.00003560309,0.00007022358,0.00005947852,0.00007131298],"domain_scores_gemma":[0.9997653,0.00002094506,0.00009656292,0.00001821934,0.00001756688,0.00008146417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009361794,0.00003484137,0.0001754292,0.00003423953,0.000006108698,0.0001113284,0.00001029438,0.00009955339,0.9986749,0.00006830664,0.00008170698,0.0006097773],"study_design_scores_gemma":[0.00006816673,0.0003750029,0.01942074,0.00005073143,0.00004373915,0.0005149562,0.00009289349,0.003861818,0.9727843,0.00009615187,0.002667404,0.00002402412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947485,0.0007842201,0.001088695,0.0001571226,0.00005163512,0.00003846444,0.001330519,0.0002316152,0.001569267],"genre_scores_gemma":[0.990357,0.0005169711,0.00171024,0.00009736833,0.000007073384,0.00004882372,0.0008679151,0.00005220227,0.006342356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003845703,"threshold_uncertainty_score":0.00764662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007806709907304078,"score_gpt":0.2924856556235534,"score_spread":0.2846789457162493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}