{"id":"W4409048803","doi":"10.1016/j.eclinm.2025.103168","title":"Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project)","year":2025,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University Health Network","funders":"National Heart, Lung, and Blood Institute; BioCryst; Swedish Orphan Biovitrum; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Direction Générale de l’offre de Soins; Deutsche Forschungsgemeinschaft; Alexion Pharmaceuticals; European Commission; Sanofi; AstraZeneca; Chugai Pharmaceutical; Amgen","keywords":"Medicine; Thrombocytopenic purpura; Retrospective cohort study; Thrombotic thrombocytopenic purpura; Cohort; Cohort study; Internal medicine; Immunology; Immune system; Pediatrics; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001514093,0.0003296824,0.0009407091,0.0002824978,0.0002174339,0.00004541656,0.0009616137,0.0001956557,0.00183346],"category_scores_gemma":[0.00278261,0.0002317473,0.0001320516,0.0005361029,0.0004449282,0.0002809143,0.000377021,0.0007538974,0.000308966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004090412,"about_ca_system_score_gemma":0.0002880281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003171448,"about_ca_topic_score_gemma":0.003888104,"domain_scores_codex":[0.9960222,0.001100214,0.001381308,0.0008135985,0.0002025439,0.0004801983],"domain_scores_gemma":[0.9965491,0.001737772,0.0003254431,0.001111994,0.0002378104,0.00003785863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005437631,0.002035226,0.9899119,0.00001240321,0.001045957,0.00004896956,0.0009601285,0.000007316248,0.001131066,0.0002983442,0.003842767,0.0001621929],"study_design_scores_gemma":[0.009070524,0.0005595369,0.9832115,0.0001681924,0.0003122333,0.0000141044,0.003791813,0.00009774337,0.00008281246,0.00004545717,0.002441376,0.0002047258],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896035,0.0005434563,0.00001464436,0.001215585,0.003127807,0.004092568,0.00007543267,0.0001310908,0.001195946],"genre_scores_gemma":[0.9964892,0.0001000814,0.00001452155,0.000419555,0.00009842923,0.0003201567,0.0005586311,0.00002250009,0.001976944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008526761,"threshold_uncertainty_score":0.999079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03948773789972432,"score_gpt":0.3635252956095043,"score_spread":0.32403755770978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}