{"id":"W4409048803","doi":"10.1016/j.eclinm.2025.103168","title":"Caplacizumab use in immune-mediated thrombotic thrombocytopenic purpura: an international multicentre retrospective Cohort study (The Capla 1000+ project)","year":2025,"lang":"en","type":"article","venue":"EClinicalMedicine","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University Health Network","funders":"National Heart, Lung, and Blood Institute; BioCryst; Swedish Orphan Biovitrum; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; Direction Générale de l’offre de Soins; Deutsche Forschungsgemeinschaft; Alexion Pharmaceuticals; European Commission; Sanofi; AstraZeneca; Chugai Pharmaceutical; Amgen","keywords":"Medicine; Thrombocytopenic purpura; Retrospective cohort study; Thrombotic thrombocytopenic purpura; Cohort; Cohort study; Internal medicine; Immunology; Immune system; Pediatrics; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001671997,0.0005101371,0.0004439121,0.0009228719,0.000433094,0.0009229203,0.0006400644,0.000628621,0.0009364853],"category_scores_gemma":[0.00196994,0.0004757364,0.0006606448,0.001545209,0.0002528997,0.0005830801,0.000556495,0.0005836525,0.0002492625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004083854,"about_ca_system_score_gemma":0.0003802195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003499695,"about_ca_topic_score_gemma":0.002786261,"domain_scores_codex":[0.9989761,0.0002790729,0.0001221506,0.0003554417,0.0001598193,0.0001074065],"domain_scores_gemma":[0.9981668,0.000171379,0.0009377153,0.0002865084,0.000190257,0.0002471964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005008803,0.00003596306,0.9981066,0.0000188818,0.000109769,0.00007314283,0.00004178509,0.00002456065,0.0001358099,0.00001545089,0.0001595201,0.0007776123],"study_design_scores_gemma":[0.0000650017,0.000369551,0.9981354,0.00002005028,0.0001189133,0.0005304184,0.00009512799,0.000181571,0.00007071281,0.00001240769,0.0003940959,0.000006722795],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979665,0.0005114007,0.0001247344,0.00002006881,0.000007104653,0.00004302732,0.001037232,0.000004108867,0.00028578],"genre_scores_gemma":[0.9976076,0.0002646465,0.0001684359,0.00004801083,0.00001985761,0.00006232464,0.001731085,0.000003300254,0.0000947202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003499695,"threshold_uncertainty_score":0.008842468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03948773789972432,"score_gpt":0.3635252956095043,"score_spread":0.32403755770978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}