{"id":"W4409052291","doi":"10.1016/j.ejca.2025.115397","title":"Inavolisib plus letrozole or fulvestrant in PIK3CA-mutated, hormone receptor-positive, HER2-negative advanced or metastatic breast cancer (GO39374): An open-label, multicentre, dose-escalation and dose-expansion phase 1/1b study","year":2025,"lang":"en","type":"article","venue":"European Journal of Cancer","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Princess Margaret Cancer Centre","funders":"Memorial Sloan-Kettering Cancer Center; Genentech Foundation","keywords":"Fulvestrant; Metastatic breast cancer; Letrozole; HER2 negative; Oncology; Medicine; Breast cancer; Internal medicine; Maximum tolerated dose; Cancer; Estrogen receptor; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009354511,0.0005263833,0.001118614,0.000478926,0.0001946995,0.0001404262,0.0004249373,0.00004690721,0.0002569271],"category_scores_gemma":[0.0001590456,0.0003714912,0.00006065922,0.001075387,0.000219332,0.001487761,0.0001662994,0.0007493697,0.000004445503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00101574,"about_ca_system_score_gemma":0.001058798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007552356,"about_ca_topic_score_gemma":0.001507955,"domain_scores_codex":[0.9958992,0.0009978906,0.001292042,0.0006257738,0.000653623,0.0005314737],"domain_scores_gemma":[0.9973323,0.0002157296,0.0008804614,0.000369065,0.0008086516,0.0003937689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1859683,0.009060872,0.003136133,0.0002100143,0.001255307,0.002301952,0.01297304,0.004803582,0.04534095,0.000009364003,0.0002454776,0.734695],"study_design_scores_gemma":[0.4241737,0.02199721,0.5036197,0.008113428,0.001760307,0.000764007,0.02668903,0.004064446,0.004752114,0.0000400948,0.002773617,0.001252327],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884858,0.005826779,0.001164534,0.001546149,0.0004776749,0.002130998,0.0001656917,0.00004066489,0.0001616905],"genre_scores_gemma":[0.9892616,0.002930547,0.005905657,0.0007144107,0.0002577132,0.00007285651,0.00001450706,0.0001150283,0.0007277378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7334427,"threshold_uncertainty_score":0.9998737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03895608083333525,"score_gpt":0.3902829151311198,"score_spread":0.3513268342977846,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}