{"id":"W4409052720","doi":"10.3748/wjg.v31.i13.104546","title":"Targeting mixed lineage kinase domain-like protein's non-necroptosis role: A new horizon in anti-inflammatory therapy for alcoholic liver disease","year":2025,"lang":"en","type":"letter","venue":"World Journal of Gastroenterology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Necroptosis; Biology; Effector; Kinase; Programmed cell death; Cell biology; Cancer research; Inflammation; Bioinformatics; Immunology; Apoptosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008792409,0.000423912,0.0006597831,0.0003168091,0.0008864208,0.001004742,0.0005871237,0.01314169,0.001989474],"category_scores_gemma":[0.00323563,0.000211252,0.0006447564,0.000228208,0.001407126,0.001621952,0.0003826266,0.01144665,0.002079979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001944669,"about_ca_system_score_gemma":0.0009971762,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006122313,"about_ca_topic_score_gemma":0.001092414,"domain_scores_codex":[0.9995613,0.0001373719,0.00005627611,0.00005688666,0.0001325031,0.00005576218],"domain_scores_gemma":[0.9987649,0.000664884,0.00009106379,0.0000568517,0.0002453335,0.0001769003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004718152,0.0002390057,0.001944322,0.0004431941,0.0000426865,0.03130631,0.0002138016,0.0004025638,0.005247498,0.01107347,0.8616179,0.08699735],"study_design_scores_gemma":[0.0002967374,0.0003518167,0.001677231,0.0002447414,0.00005236192,0.02864376,0.000256066,0.002062008,0.003949204,0.02643786,0.9359572,0.00007110668],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.0042414,0.0140095,0.0008476991,0.950056,0.02691605,0.00002548087,0.00004951122,0.00009942343,0.003754864],"genre_scores_gemma":[0.05729022,0.03070472,0.002416645,0.7701112,0.1163659,0.0001147007,0.00008293964,0.00005614621,0.02285759],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01314169,"threshold_uncertainty_score":0.01410967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006118134975652018,"score_gpt":0.2204662110544894,"score_spread":0.2143480760788374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}