{"id":"W4409054632","doi":"10.1021/acschemneuro.5c00074","title":"Caffeine and Nicotine with N-Substituted Diazirine Photoaffinity Labels Form Adducts at Tyrosine-39 of α-Synuclein","year":2025,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; College of Pharmacy and Nutrition, University of Saskatchewan","keywords":"Diazirine; Nicotine; Photoaffinity labeling; Chemistry; Tyrosine; Caffeine; Adduct; Stereochemistry; Pharmacology; Biochemistry; Neuroscience; Organic chemistry; Psychology; Biology; Binding site; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001227682,0.0003392661,0.0002169727,0.0001142325,0.0001831173,0.0001022526,0.0003566727,0.0004559896,0.0008884701],"category_scores_gemma":[0.000139054,0.0001634896,0.0002986806,0.00009291085,0.0001605128,0.0001593492,0.0001535573,0.000392253,0.0002886959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003061231,"about_ca_system_score_gemma":0.0001459004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105149,"about_ca_topic_score_gemma":0.002281547,"domain_scores_codex":[0.9998592,0.00002161013,0.000005627579,0.00005014046,0.00003228826,0.00003114409],"domain_scores_gemma":[0.9999237,0.00001800327,0.00002722015,0.000009445257,0.0000087213,0.00001301816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004561758,0.000009196387,0.00007281726,0.00001831046,0.000004065776,0.00003008147,0.000009326113,0.0000214037,0.9994136,0.00003054102,0.000009663778,0.0003352828],"study_design_scores_gemma":[0.000009051314,0.000262893,0.00265978,0.00000419181,0.00001428104,0.0001712308,0.00001153545,0.0005260985,0.9952921,0.00001758102,0.001026387,0.000005036172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928824,0.00141524,0.003350411,0.00008643842,0.00001617596,0.00003948855,0.00008570786,0.00003774987,0.002086405],"genre_scores_gemma":[0.9880942,0.001188652,0.00699132,0.0001067788,0.00001015105,0.00005738743,0.0002741757,0.0000188448,0.003258547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105149,"threshold_uncertainty_score":0.002972245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132483807091906,"score_gpt":0.2508580176359025,"score_spread":0.2295331795649834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}