{"id":"W4409060805","doi":"10.1177/10915818251327963","title":"Cardiovascular and Pharmacokinetic Profiles of Intravenous Etripamil in Conscious Telemetered Cynomolgus Monkeys","year":2025,"lang":"en","type":"article","venue":"International Journal of Toxicology","topic":"Cardiac Arrhythmias and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vertex Pharmaceuticals (Canada)","funders":"","keywords":"Medicine; Pharmacokinetics; Blood pressure; Dosing; Heart rate; Nasal administration; Anesthesia; Dihydropyridine; Ventricular tachycardia; Pharmacology; Internal medicine; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002004217,0.00008658679,0.0004569663,0.0004938639,0.000009871688,0.000006282373,0.00008747557,0.00006777073,0.00003826485],"category_scores_gemma":[0.0001528486,0.00007276002,0.0002171823,0.0001040625,0.00008831844,0.00003692489,0.00005111289,0.0001611322,9.807425e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001288675,"about_ca_system_score_gemma":0.0001599738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000591683,"about_ca_topic_score_gemma":0.00001071198,"domain_scores_codex":[0.9990365,0.00006588835,0.0004492622,0.0001062419,0.0002356589,0.0001064729],"domain_scores_gemma":[0.9992931,0.0001144428,0.0001607168,0.00008280335,0.0002997689,0.0000491893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00387004,0.001803602,0.3851816,0.0002142137,0.01830882,0.0139227,0.001034234,0.00080289,0.04721232,0.001012732,0.001349705,0.5252872],"study_design_scores_gemma":[0.0286474,0.00196,0.8681435,0.0006633555,0.001606513,0.009417005,0.0002726455,0.0003400557,0.07215963,0.001672999,0.01489026,0.0002266261],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924526,0.004115361,0.0002071329,0.0009918142,0.0009058406,0.0001742687,0.00001527929,0.000003235333,0.001134448],"genre_scores_gemma":[0.9980597,0.0008782333,0.0006246681,0.0002121524,0.0001273474,0.00000549195,0.000003278078,0.000005714419,0.00008341135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5250605,"threshold_uncertainty_score":0.2967068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009957908255201278,"score_gpt":0.3026997800679906,"score_spread":0.2927418718127893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}