{"id":"W4409067233","doi":"10.1016/j.ahj.2025.03.015","title":"Rationale and design of NUDGE-CKD: A nationwide randomized factorial trial of electronic nudges for increasing guideline-directed medical therapy in chronic kidney disease","year":2025,"lang":"en","type":"article","venue":"American Heart Journal","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"Danish Cardiovascular Academy; Respicardia; American Regent; Sanofi Pasteur; National Institutes of Health; Seqirus; Region Hovedstaden; Novo Nordisk; GlaxoSmithKline; Gedeon Richter; Servier; Pfizer; Moderna; Sarepta Therapeutics; Dansk Nefrologisk Selskab; Cytokinetics; Novo Nordisk Fonden; Boston Scientific Corporation; National Heart, Lung, and Blood Institute; Acceleron; Alnylam Pharmaceuticals; Hjerteforeningen; Alexion Pharmaceuticals; Sanofi; Amgen; Vifor Pharma; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Nudge theory; Kidney disease; Guideline; Randomized controlled trial; Clinical trial; Physical therapy; Intensive care medicine; Family medicine; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04121503,0.005539203,0.005783807,0.001455782,0.002149509,0.002734425,0.00275074,0.006527526,0.01728588],"category_scores_gemma":[0.03055068,0.002649363,0.002702908,0.001344134,0.004215466,0.002409642,0.001722784,0.004710721,0.003409444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002229741,"about_ca_system_score_gemma":0.008607442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001278436,"about_ca_topic_score_gemma":0.001891795,"domain_scores_codex":[0.9654438,0.02560424,0.001790511,0.003164691,0.00201341,0.001983337],"domain_scores_gemma":[0.9879049,0.005530366,0.002127324,0.001282543,0.001294571,0.001860176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9327592,0.02255869,0.002955372,0.006081196,0.002454877,0.0002261794,0.0004636508,0.002586037,0.002136031,0.007337666,0.005271808,0.01516936],"study_design_scores_gemma":[0.908234,0.06503625,0.003006047,0.0007496503,0.001973666,0.00008029304,0.0001198245,0.003160252,0.0007916866,0.00616274,0.01058902,0.00009664227],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"empirical","genre_scores_codex":[0.05041705,0.001394283,0.007594543,0.002317226,0.002041613,0.9301827,0.0023842,0.0002199978,0.003448452],"genre_scores_gemma":[0.04495251,0.0002764999,0.01237718,0.001327179,0.0002340685,0.9393317,0.0003381777,0.00001005641,0.00115261],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.04121503,"threshold_uncertainty_score":0.2179685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01801866420224898,"score_gpt":0.329276373518729,"score_spread":0.3112577093164801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}