{"id":"W4409069741","doi":"10.1186/s12964-025-02142-x","title":"DNM1L-mediated fission governs mitophagy & mitochondrial biogenesis during myogenic differentiation","year":2025,"lang":"en","type":"article","venue":"Cell Communication and Signaling","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNM1L; Mitophagy; Mitochondrial fission; Cell biology; Myogenesis; Mitochondrial biogenesis; Biology; PPARGC1A; C2C12; Mitochondrion; Myocyte; Genetics; Coactivator; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008512073,0.0001406591,0.0002066915,0.0001352362,0.0003112,0.0000402879,0.0001438295,0.0001218581,0.0002710374],"category_scores_gemma":[0.00005559341,0.0001312576,0.00009905858,0.0002193663,0.00004791803,0.00006846002,0.00008979215,0.0001538332,0.00002491405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005968405,"about_ca_system_score_gemma":0.00005566458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003376249,"about_ca_topic_score_gemma":0.000007894744,"domain_scores_codex":[0.9990794,0.0001247381,0.0002896356,0.0002052328,0.0001494791,0.0001515169],"domain_scores_gemma":[0.9990112,0.0001512597,0.0001105785,0.0005505598,0.00007558856,0.0001007867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003006274,0.0001943562,0.00639781,0.000128761,0.00008574239,0.000001612068,0.0003558889,0.00001052656,0.991116,0.0001126387,0.00033056,0.0009654199],"study_design_scores_gemma":[0.005878705,0.00005215217,0.1063176,0.0004497094,0.0003045659,0.000005172281,0.00031289,0.00121026,0.8765609,0.0005841378,0.0080143,0.0003096506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888082,0.008279951,0.0008767312,0.000408173,0.0001245492,0.0002749808,0.00001020894,0.00009220071,0.001125034],"genre_scores_gemma":[0.9938079,0.002316681,0.0006570955,0.0003169579,0.00006401745,0.0000263296,0.0003378492,0.00001598569,0.002457229],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1145552,"threshold_uncertainty_score":0.5352529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01100227228512918,"score_gpt":0.2611366033634251,"score_spread":0.2501343310782959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}