{"id":"W4409088113","doi":"10.54985/peeref.2504a6158246","title":"Pharmacology and Chemistry of Collybolide, Salvinorin A, and Mitragynine: Natural Product-Based Pain Therapeutics","year":2025,"lang":"en","type":"article","venue":"","topic":"Alkaloids: synthesis and pharmacology","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"George Brown College","funders":"","keywords":"Natural product; Pharmacology; Chemistry; Natural (archaeology); Traditional medicine; Medicine; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001040802,0.0001965193,0.0001119954,0.0001850252,0.0001889311,0.0001851736,0.0001849451,0.0002398215,0.001572135],"category_scores_gemma":[0.00005708146,0.00007104677,0.0001057939,0.00008140638,0.0002923102,0.000287441,0.0001819123,0.0003274744,0.0002257739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000263787,"about_ca_system_score_gemma":0.0002509587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007151544,"about_ca_topic_score_gemma":0.001490185,"domain_scores_codex":[0.9999747,0.000007934193,0.000001505514,0.000004037941,0.000005086466,0.000006570848],"domain_scores_gemma":[0.999969,0.00000374078,0.00001164418,0.000002389455,0.000005268523,0.000007972237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008474045,0.0001867046,0.0005615205,0.000722185,0.00003070368,0.0006685058,0.0002166439,0.0007534988,0.9300199,0.01247451,0.001068397,0.05245005],"study_design_scores_gemma":[0.0003223155,0.008734768,0.02238993,0.0001756406,0.0001314934,0.004291144,0.0003230298,0.002652096,0.8137563,0.006556261,0.1405946,0.00007220572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.814468,0.1499324,0.005387243,0.002485516,0.0002036817,0.0001136045,0.000266943,0.0001470233,0.02699548],"genre_scores_gemma":[0.9575652,0.03297716,0.001448832,0.0002352728,0.0001362624,0.00002436214,0.00008775051,0.00000751601,0.007517577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572135,"threshold_uncertainty_score":0.005259335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03714864339999705,"score_gpt":0.3921430467779402,"score_spread":0.3549944033779431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}