{"id":"W4409099001","doi":"10.1016/j.ijrobp.2025.03.038","title":"Radiation Therapy Dose Escalation Failed to Improve Local Control for Intermediate-Risk Rhabdomyosarcoma on ARST1431: A Report From the Children’s Oncology Group","year":2025,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"National Institutes of Health; Children’s Oncology Group; National Cancer Institute; St. Baldrick's Foundation","keywords":"Radiation therapy; Rhabdomyosarcoma; Medicine; Oncology; Internal medicine; Radiation oncology; Sarcoma; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001243671,0.0004290534,0.001039241,0.0003239661,0.0005954831,0.0005893217,0.0007469989,0.00129613,0.001272104],"category_scores_gemma":[0.002297481,0.0002263185,0.001204633,0.0003639353,0.0005935362,0.0003369109,0.0003039041,0.002471472,0.0003339527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001510487,"about_ca_system_score_gemma":0.0009062518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004467546,"about_ca_topic_score_gemma":0.008233664,"domain_scores_codex":[0.9993017,0.0001364995,0.00006639784,0.0001042776,0.0002208134,0.0001703032],"domain_scores_gemma":[0.9984096,0.0007980453,0.0001813309,0.000187471,0.0001380297,0.0002854519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02066304,0.005789652,0.2767767,0.0007828264,0.001714868,0.07678767,0.001678955,0.008858808,0.1691168,0.00165975,0.02659148,0.4095796],"study_design_scores_gemma":[0.003647518,0.0712491,0.6342672,0.0002410654,0.002363751,0.09554188,0.001072065,0.007475072,0.1275432,0.00137513,0.05503063,0.0001934185],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986353,0.002401868,0.0009508944,0.003716338,0.0001399942,0.0001604588,0.0005106438,0.0001051043,0.00566154],"genre_scores_gemma":[0.9945528,0.0009936675,0.0007337452,0.001774066,0.00006286111,0.00004356654,0.0006749459,0.0001014669,0.001062886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004467546,"threshold_uncertainty_score":0.01095939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01235579586731386,"score_gpt":0.3251893430132467,"score_spread":0.3128335471459329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}