{"id":"W4409109882","doi":"10.1021/acsmedchemlett.5c00081","title":"Synthesis, Radiosynthesis, in Vitro and in Vivo Evaluation of the GABA<sub>A</sub>-Benzodiazepine Receptor Agonist [<sup>11</sup>C]RO6899880","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Azrieli Foundation; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"Radiosynthesis; Agonist; In vivo; Benzodiazepine; In vitro; Chemistry; Receptor; Pharmacology; GABAA receptor; Medicine; Biochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001511728,0.0002464629,0.0003641277,0.0001983206,0.0001616212,0.00003180815,0.0007254166,0.0001090258,0.00005745102],"category_scores_gemma":[0.004104401,0.000201672,0.00006691233,0.001139735,0.001049717,0.0001510324,0.0002006319,0.0005949846,0.000003651217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001913642,"about_ca_system_score_gemma":0.0002822522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001973532,"about_ca_topic_score_gemma":0.00000559889,"domain_scores_codex":[0.9965233,0.0006905672,0.0004799571,0.0007450135,0.001024726,0.000536448],"domain_scores_gemma":[0.9978594,0.001405537,0.0001452955,0.0004342335,0.0000517601,0.0001038397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001846325,0.0001009024,0.001529002,0.0001328959,0.000003698269,0.00004283181,0.0001065521,0.0001166087,0.995131,0.000002215305,0.001093086,0.001556593],"study_design_scores_gemma":[0.0008874564,0.000009937911,0.001279951,0.0001952224,0.0000449503,0.00003275782,0.00008799978,0.001525822,0.9954547,0.00001625149,0.0003204512,0.0001445071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858234,0.000117729,0.000002075993,0.01310335,0.0001650325,0.0004566594,0.00002784,0.00001917111,0.0002847396],"genre_scores_gemma":[0.9957559,0.0002989209,0.000004594824,0.003697437,0.0000720386,0.0001191155,7.348199e-7,0.00001662315,0.00003467956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009932451,"threshold_uncertainty_score":0.8223947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552632660860187,"score_gpt":0.2980924668732672,"score_spread":0.2725661402646653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}