{"id":"W4409109882","doi":"10.1021/acsmedchemlett.5c00081","title":"Synthesis, Radiosynthesis, in Vitro and in Vivo Evaluation of the GABA<sub>A</sub>-Benzodiazepine Receptor Agonist [<sup>11</sup>C]RO6899880","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Azrieli Foundation; Canada Research Chairs; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canada Foundation for Innovation; Ontario Research Foundation","keywords":"Radiosynthesis; Agonist; In vivo; Benzodiazepine; In vitro; Chemistry; Receptor; Pharmacology; GABAA receptor; Medicine; Biochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000213858,0.0004402322,0.0002536947,0.0001824002,0.000174373,0.0001962311,0.0003306161,0.0002785656,0.001261337],"category_scores_gemma":[0.0001738378,0.0002092415,0.0001733936,0.0001721635,0.0001548333,0.0002157576,0.0001598237,0.0002830237,0.0009904319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002130295,"about_ca_system_score_gemma":0.0002352446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006308754,"about_ca_topic_score_gemma":0.0008789003,"domain_scores_codex":[0.9999123,0.00002526501,0.000009108276,0.00001727682,0.00001704203,0.00001902444],"domain_scores_gemma":[0.9998862,0.00001561961,0.00003432031,0.00001814458,0.0000280732,0.00001759844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001370848,0.00002409154,0.00005984726,0.00004502029,0.000005554629,0.00007037715,0.00001734715,0.0001919493,0.9972971,0.00007919594,0.00003805651,0.00203442],"study_design_scores_gemma":[0.0000277776,0.000867443,0.0005742338,0.000004346739,0.00002781468,0.0004976563,0.00001795414,0.0003008886,0.9930396,0.00002357933,0.004611918,0.000006730601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702608,0.00345998,0.021582,0.00009636312,0.00002424132,0.000244251,0.0006237046,0.0001753438,0.00353333],"genre_scores_gemma":[0.951508,0.00410623,0.03596955,0.0001329569,0.00003048374,0.0002359899,0.001502458,0.0001326466,0.006381567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001261337,"threshold_uncertainty_score":0.004219532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552632660860187,"score_gpt":0.2980924668732672,"score_spread":0.2725661402646653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}