{"id":"W4409111255","doi":"10.1016/s0140-6736(25)00507-0","title":"Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; St. Michael's Hospital","funders":"NIHR Imperial Biomedical Research Centre; Eli Lilly and Company","keywords":"Double blind; Medicine; Placebo; Internal medicine; Pharmacology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002175014,0.0002963534,0.001818434,0.0001820271,0.0000976576,0.00003146926,0.0002140701,0.0001541333,0.00003769468],"category_scores_gemma":[0.001552067,0.0001718596,0.0001659986,0.0005204151,0.000266073,0.00009990268,0.00006273553,0.0004302755,0.000002824357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002977016,"about_ca_system_score_gemma":0.0002912238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002565786,"about_ca_topic_score_gemma":0.0002532844,"domain_scores_codex":[0.9976246,0.0003607095,0.000798733,0.0004426851,0.00031012,0.0004631279],"domain_scores_gemma":[0.997875,0.0009514221,0.0002892185,0.0006291017,0.0001498614,0.0001054475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.989049,0.0007628855,0.002972574,0.0004331551,0.0002603583,0.00001051652,0.001319957,0.00002523611,0.002565436,0.0001898555,0.0009203223,0.001490674],"study_design_scores_gemma":[0.9930568,0.0005403478,0.001982483,0.0004299875,0.0005163809,0.000005119863,0.0005408868,0.0005702588,0.001786241,0.00009493507,0.0003052922,0.0001712103],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861792,0.001817242,0.00005974287,0.002485318,0.0003132615,0.007148132,0.00001856867,0.00007346027,0.001905092],"genre_scores_gemma":[0.9981112,0.000164625,0.0001922185,0.0004008038,0.0005723919,0.0003813456,0.00004376124,0.00002171214,0.0001119176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01193204,"threshold_uncertainty_score":0.7008231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985226370976373,"score_gpt":0.3001661460997056,"score_spread":0.2803138823899419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}