{"id":"W4409112844","doi":"10.1002/art.43168","title":"Anti–Peptidylarginine Deiminase 4 Autoantibodies Derived From Patients With Rheumatoid Arthritis Exert Pathogenic Effects by Activating Monocytes and Exacerbating Inflammatory Arthritis","year":2025,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; Bristol-Myers Squibb Canada; National Cancer Institute; National Institutes of Health; AstraZeneca; Celgene; Johns Hopkins University; Pfizer; Bristol-Myers Squibb; American Heart Association","keywords":"Immunology; Autoantibody; Antibody; Arthritis; Fibroblast; Medicine; Immune system; Monocyte; Inflammation; Peripheral blood mononuclear cell; Chemokine; Rheumatoid arthritis; Biology; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003043703,0.0007284137,0.0004392505,0.0005313797,0.0002066147,0.0003270398,0.0001619976,0.0004035365,0.001536496],"category_scores_gemma":[0.0003543301,0.0001643966,0.0003460513,0.0002791324,0.0002012349,0.0001316312,0.00022283,0.0005782435,0.0004714988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001466423,"about_ca_system_score_gemma":0.0001567964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001930533,"about_ca_topic_score_gemma":0.0003313917,"domain_scores_codex":[0.9995564,0.0000866487,0.00005352484,0.00009637172,0.0001307372,0.00007641035],"domain_scores_gemma":[0.9996806,0.00006032465,0.0001351918,0.00002466415,0.00004019637,0.00005907854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008633918,0.000123945,0.02163306,0.0002118491,0.00006584651,0.0009613876,0.0000496964,0.00007462056,0.96798,0.00002306212,0.0001571225,0.007855988],"study_design_scores_gemma":[0.0003506691,0.008038445,0.5025898,0.0001115249,0.0004433526,0.02120807,0.0002931576,0.001020135,0.4567517,0.0001468469,0.009014805,0.00003147101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994556,0.00326647,0.0009592149,0.00008954173,0.00003962568,0.00002985865,0.0002144971,0.00004266262,0.0008022134],"genre_scores_gemma":[0.9970099,0.0009976845,0.0008408745,0.0001207998,0.0000624227,0.00003396343,0.0003874142,0.000005955435,0.0005409335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536496,"threshold_uncertainty_score":0.005140066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003903209167385801,"score_gpt":0.2204000774700858,"score_spread":0.2164968683027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}