{"id":"W4409119362","doi":"10.1093/hmg/ddaf040","title":"CRISPR-Cas9-driven antigen conversion of clinically relevant blood group systems","year":2025,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Centre hospitalier universitaire de Québec; Héma-Québec","funders":"Centre Hospitalier Universitaire de Québec; Mitacs; Université Laval","keywords":"Biology; CRISPR; Antigen; Genetics; Cas9; Computational biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005143613,0.0004997108,0.0003930956,0.0002976106,0.0002555516,0.0008713357,0.0006879777,0.000754735,0.002538533],"category_scores_gemma":[0.0008671518,0.0003061993,0.0003974104,0.0001634549,0.0004903558,0.0002974666,0.0007653437,0.00130165,0.0009155893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004621494,"about_ca_system_score_gemma":0.0005330528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006979828,"about_ca_topic_score_gemma":0.001173907,"domain_scores_codex":[0.9995251,0.00006463685,0.00007279497,0.0001302825,0.0001354299,0.00007176262],"domain_scores_gemma":[0.9996223,0.0001071377,0.00008034726,0.00008543374,0.00004050804,0.0000641962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009614885,0.00004790617,0.0003240831,0.0001459211,0.00002013539,0.0003018453,0.00009011107,0.0009168754,0.9882902,0.002017795,0.0005039723,0.007245139],"study_design_scores_gemma":[0.00003069559,0.0001675928,0.00122512,0.00003420694,0.00003796259,0.0007113314,0.00004437617,0.006141351,0.9590896,0.0006991485,0.03178521,0.000033411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7102428,0.001738072,0.2586305,0.0007183999,0.0006184956,0.0008541611,0.003758078,0.003965205,0.01947434],"genre_scores_gemma":[0.9079347,0.000849041,0.07575741,0.0002875707,0.00002763488,0.0003503808,0.003048355,0.0005925303,0.01115245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002538533,"threshold_uncertainty_score":0.008492231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008114980771581173,"score_gpt":0.3118520058025478,"score_spread":0.3037370250309667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}