{"id":"W4409119637","doi":"10.1128/mbio.03318-24","title":"Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in <i>Trypanosoma cruzi</i>","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council Canada; National Institutes of Health; Volkswagen Foundation; Deutsche Forschungsgemeinschaft; American Heart Association","keywords":"Inositol; Phospholipase C; Biochemistry; Diacylglycerol kinase; Phosphatidylinositol; Biology; Sphingolipid; Inositol phosphate; Phosphorylation; Phosphoinositide phospholipase C; Sugar phosphates; Phospholipase; Inositol trisphosphate receptor; Cytosol; Second messenger system; Inositol trisphosphate; Kinase; Signal transduction; Enzyme; Protein kinase C; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00002384145,0.0001792643,0.000390159,0.0002257745,0.0001056336,0.0000531105,0.0001279034,0.000128898,0.00003962845],"category_scores_gemma":[0.000192344,0.0001646434,0.00007462181,0.0006650356,0.0001305468,0.0002207112,0.0001387435,0.0002572209,0.00000671043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009115694,"about_ca_system_score_gemma":0.0002701524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001776215,"about_ca_topic_score_gemma":0.0003865516,"domain_scores_codex":[0.9985,0.00005365408,0.0004477499,0.0003646765,0.0002825223,0.0003513309],"domain_scores_gemma":[0.9991612,0.00006305697,0.00009240171,0.0004172406,0.00014419,0.0001218997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000759721,0.0002311649,0.008180878,0.000113635,0.00005171671,0.00001663419,0.0005985006,0.000003307835,0.9779364,0.009874498,0.001092986,0.00182434],"study_design_scores_gemma":[0.001610985,0.00007189242,0.3339131,0.0001360743,0.00003963968,0.00001266473,0.0002335599,0.0005688625,0.6558631,0.0006405777,0.006783944,0.0001255229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847456,0.009944539,0.000164038,0.002130235,0.0002084736,0.0005955594,0.00004080975,0.00004119646,0.002129545],"genre_scores_gemma":[0.996544,0.0009501749,0.0008744628,0.0007282135,0.0001208435,0.00009124802,0.00004441933,0.00001705819,0.0006295965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3257323,"threshold_uncertainty_score":0.6713961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03522965889984811,"score_gpt":0.3039946346811068,"score_spread":0.2687649757812587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}