{"id":"W4409119637","doi":"10.1128/mbio.03318-24","title":"Generation of inositol polyphosphates through a phospholipase C-independent pathway involving carbohydrate and sphingolipid metabolism in <i>Trypanosoma cruzi</i>","year":2025,"lang":"en","type":"article","venue":"mBio","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Medical Research Council Canada; National Institutes of Health; Volkswagen Foundation; Deutsche Forschungsgemeinschaft; American Heart Association","keywords":"Inositol; Phospholipase C; Biochemistry; Diacylglycerol kinase; Phosphatidylinositol; Biology; Sphingolipid; Inositol phosphate; Phosphorylation; Phosphoinositide phospholipase C; Sugar phosphates; Phospholipase; Inositol trisphosphate receptor; Cytosol; Second messenger system; Inositol trisphosphate; Kinase; Signal transduction; Enzyme; Protein kinase C; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008375034,0.000240389,0.0001582409,0.0001787387,0.0001821878,0.0003116621,0.0001708588,0.0002051866,0.0003530468],"category_scores_gemma":[0.00008676392,0.00009961426,0.0001806444,0.0001290445,0.0001622702,0.000130857,0.0001768812,0.000348331,0.000278923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006278427,"about_ca_system_score_gemma":0.0002336007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400053,"about_ca_topic_score_gemma":0.001562069,"domain_scores_codex":[0.9999321,0.000008211447,0.000007762515,0.00001507096,0.0000201864,0.00001679131],"domain_scores_gemma":[0.9999319,0.000008964992,0.00002276648,0.00000695865,0.00001101745,0.00001839278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003829669,0.000006114459,0.0002922432,0.00002085424,0.000001455521,0.00007204638,0.000009753013,0.00003579769,0.9991164,0.00007719961,0.00002012522,0.000309671],"study_design_scores_gemma":[0.00001618716,0.0000831366,0.01164392,0.000007883838,0.00001517787,0.0006897543,0.00006064222,0.001427728,0.9835118,0.00006107193,0.002476288,0.000006419843],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958631,0.0007466415,0.001825206,0.0001028988,0.00001480743,0.00001956819,0.0005494147,0.00004132985,0.000836968],"genre_scores_gemma":[0.9953204,0.0003795691,0.001241819,0.00003876267,0.000004572761,0.0000179264,0.001535658,0.00001473072,0.001446515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400053,"threshold_uncertainty_score":0.004555345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03522965889984811,"score_gpt":0.3039946346811068,"score_spread":0.2687649757812587,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}