{"id":"W4409119752","doi":"10.1139/bcb-2025-0062","title":"Lysosomal enzyme processing and trafficking in the social amoeba <i>Dictyostelium discoideum</i>","year":2025,"lang":"en","type":"review","venue":"Biochemistry and Cell Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trent University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dictyostelium discoideum; Biology; Eukaryote; Multicellular organism; Chemotaxis; Cell biology; Amoeba (genus); Dictyostelium; Biochemistry; Cell; Gene; Genome; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003146176,0.0006646959,0.0007215033,0.002239326,0.0002468045,0.0008155532,0.0004793756,0.0007318412,0.001458444],"category_scores_gemma":[0.0003648474,0.0002951293,0.000333821,0.001981294,0.0003111505,0.00110837,0.0005474714,0.0008994734,0.001602766],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007041462,"about_ca_system_score_gemma":0.001015698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539549,"about_ca_topic_score_gemma":0.002222921,"domain_scores_codex":[0.9999026,0.00001043068,0.00001759779,0.00002112549,0.0000358514,0.00001234734],"domain_scores_gemma":[0.9998916,0.00003135945,0.0000234712,0.000003825066,0.00003326089,0.00001641422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001001286,0.00003786813,0.0002254082,0.02090685,0.0000661684,0.0002117764,0.00007792699,0.0004291271,0.009298669,0.003860213,0.01826967,0.9465162],"study_design_scores_gemma":[0.000009143595,0.00008114977,0.001214046,0.002122713,0.00008843993,0.0008533907,0.00004208357,0.00008440406,0.002404629,0.001303279,0.9917773,0.00001940453],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001562447,0.9987909,0.0001037054,0.0001181989,0.00005872859,0.000002268207,0.0000233935,0.000007201828,0.0007394084],"genre_scores_gemma":[0.0006665546,0.9986267,0.0001415134,0.00006880098,0.00003563593,0.000003370744,0.0000413403,0.000001095619,0.0004150105],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002239326,"threshold_uncertainty_score":0.005108893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262568969977362,"score_gpt":0.2672734893627087,"score_spread":0.2546477996629351,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}