{"id":"W4409123580","doi":"10.1002/j.2040-4603.2021.tb00172.x","title":"Function and Regulation of the Epithelial Na <sup>+</sup> Channel <scp>ENaC</scp>","year":2021,"lang":"en","type":"article","venue":"Comprehensive physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; Fondation Leducq; Cystic Fibrosis Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Epithelial sodium channel; Function (biology); Cell biology; Channel (broadcasting); Chemistry; Sodium; Biology; Computer science; Computer network","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002102382,0.0002500894,0.0001963383,0.0002030059,0.0002470929,0.000579231,0.0002963877,0.0003578047,0.001411275],"category_scores_gemma":[0.0001932218,0.00008501056,0.0002453073,0.0001521103,0.000350781,0.0003623926,0.0002997989,0.0005087684,0.0005275043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000385513,"about_ca_system_score_gemma":0.0002780103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001039602,"about_ca_topic_score_gemma":0.0005745076,"domain_scores_codex":[0.9998434,0.00002741795,0.00001604107,0.00003447847,0.000055406,0.00002316975],"domain_scores_gemma":[0.9998362,0.00002209061,0.00003775111,0.00001214849,0.00004768552,0.00004410236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003571428,0.00002392735,0.001309596,0.0001158252,0.00001613814,0.0004474655,0.00002821854,0.00016053,0.991731,0.001327305,0.0005033548,0.003979435],"study_design_scores_gemma":[0.00007588209,0.0003933793,0.05967804,0.00003815817,0.0000767377,0.004215328,0.0002216687,0.006998665,0.8986353,0.001630542,0.02799881,0.00003753571],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9588951,0.02559524,0.007154215,0.001025949,0.0002332535,0.00002507938,0.0008479517,0.0001382829,0.006084763],"genre_scores_gemma":[0.9917501,0.003323022,0.0008651128,0.0002547871,0.00003164459,0.00001729427,0.0007109288,0.000023941,0.003023094],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001411275,"threshold_uncertainty_score":0.004721224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01139788873401021,"score_gpt":0.2117014662314737,"score_spread":0.2003035774974634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}